Clinical features and long‐term outcome of obesity‐associated focal segmental glomerulosclerosis
| Autor: | María Angeles Valero, Miguel León, Miguel Angel Martínez, Enrique Morales, Ana Pérez Campos, Manuel Praga, E. Hernandez |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Kidney Glomerulus Renal function Angiotensin-Converting Enzyme Inhibitors Gastroenterology chemistry.chemical_compound Focal segmental glomerulosclerosis Internal medicine medicine Humans Longitudinal Studies Obesity Renal Insufficiency Aged Transplantation Creatinine Proteinuria Glomerulosclerosis Focal Segmental business.industry Glomerulosclerosis Middle Aged Prognosis medicine.disease Survival Analysis Surgery Treatment Outcome chemistry Nephrology Female Hemodialysis medicine.symptom business Nephrotic syndrome Kidney disease |
| Zdroj: | Nephrology Dialysis Transplantation. 16:1790-1798 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/16.9.1790 |
| Popis: | BACKGROUND Several cases of obesity-associated focal segmental glomerulosclerosis (OB-FSG) have been reported but little is known about the clinico-pathological features of this entity and its long-term outcomes. METHODS We studied 15 obese patients (BMI 35+/-5.2 kg/m(2)) with biopsy-proven FSG. They were compared with a control group of 15 non-obese patients with idiopathic FSG (I-FSG). RESULTS Mean proteinuria at the time of renal biopsy was 3.1+/-2 g/24 h in OB-FSG; it reached the nephrotic range (> or =3.5 g/24 h) during follow-up in 12 patients (80%), but none of them had oedema, hypoproteinaemia, or hypoalbuminaemia. Proteinuria was more marked amongst I-FSG (6.5+/-4.2 g/24 h) and most of them developed oedema and biochemical nephrotic syndrome. Glomerulomegaly was observed in all renal biopsies from OB-FSG patients (mean glomerular diameter 256+/-24 microm in OB-FSG vs 199+/-26 microm in I-FSG, P |
| Databáze: | OpenAIRE |
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