Effect of increasing carbon chain length on organic acid transport by the choroid plexus: a potential factor in Reye's syndrome
| Autor: | C.S. Kim, J.D. Mann, L.A. O'Tuama, Charles R. Roe |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
2 4-Dichlorophenoxyacetic acid Intracranial Pressure Hydroxybutyrates chemistry.chemical_compound medicine Animals 3-Hydroxybutyric Acid Reye's syndrome Caproates Molecular Biology Carbon chain chemistry.chemical_classification Brain uptake Chemistry Reye Syndrome Valproic Acid General Neuroscience Organic acid transport medicine.disease Molecular Weight Biochemistry Blood-Brain Barrier Choroid Plexus Tyrosine Female Choroid plexus Rabbits Neurology (clinical) 2 4-Dichlorophenoxyacetic Acid Caprylates Acids Decanoic Acids Developmental Biology Organic acid |
| Zdroj: | Brain Research. 259:340-343 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(83)91271-4 |
| Popis: | Transport of the anionic herbicide 2,4-dichlorophenoxyacetic acid by choroid plexus is inhibited significantly by several short and medium chain acids. For both monocarboxylic and dicarboxylic homologs, inhibition clearly increases with chain length. It appears that organic acid compounds of longer chain length, higher brain uptake index, and highest inhibition of choroid plexus transport would be the ones producing the most significant increases in intracranial pressure in metabolic encephalopathy such as Reye's syndrome. |
| Databáze: | OpenAIRE |
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