Rapid HIV disease progression following superinfection in an HLA-B*27:05/B*57:01-positive transmission recipient

Autor:	Paul Kellam, Philippa C Matthews, Todd M. Allen, Astrid Gall, Reena R. D’Souza, Jacqui Brener, Oliver G. Pybus, Nora Lavandier, Fabian Chen, Anne Edwards, Rebecca Batorsky, Jacob Hurst, Chrissy Bolton, Philip J. R. Goulder
Přispěvatelé:	Brener, Jacqui [0000-0002-6528-6471], Apollo - University of Cambridge Repository
Rok vydání:	2018
Předmět:	HLA CLASS-I CD4-Positive T-Lymphocytes Male 0301 basic medicine Medizin HIV Core Protein p24 Epitopes T-Lymphocyte HIV Infections Virus Replication medicine.disease_cause gag Gene Products Human Immunodeficiency Virus INFECTION Cluster Analysis Cytotoxic T cell GAG CTL response biology High-Throughput Nucleotide Sequencing IMMUNODEFICIENCY-VIRUS TYPE-1 Viral Load 3. Good health HLA Infectious Diseases Superinfection ESCAPE MUTATIONS Disease Progression RNA Viral Transmission pair Antibody Life Sciences & Biomedicine Viral load lcsh:Immunologic diseases. Allergy Ultra-deep sequencing GENOMES Human leukocyte antigen CD8(+) T-CELLS REPLICATION CAPACITY Virus 03 medical and health sciences Virology medicine Humans Science & Technology Sequence Analysis RNA Research Genetic Variation 1103 Clinical Sciences REPORTER CELL-LINE CD4 Lymphocyte Count CTL 030104 developmental biology Amino Acid Substitution HLA-B Antigens HIV-1 biology.protein lcsh:RC581-607 CD8 T-Lymphocytes Cytotoxic
Zdroj:	Retrovirology, Vol 15, Iss 1, Pp 1-13 (2018) Retrovirology
ISSN:	1742-4690
DOI:	10.1186/s12977-018-0390-9
Popis:	Background The factors determining differential HIV disease outcome among individuals expressing protective HLA alleles such as HLA-B*27:05 and HLA-B*57:01 remain unknown. We here analyse two HIV-infected subjects expressing both HLA-B*27:05 and HLA-B*57:01. One subject maintained low-to-undetectable viral loads for more than a decade of follow up. The other progressed to AIDS in
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98683002505acb3d7f005d8515c6244b https://doi.org/10.1186/s12977-018-0390-9 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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