Serum calcium and long-term outcome after ischemic stroke: Results from the China National stroke registry III
| Autor: | Jing Jing, Zheng-Chang Jia, Xiao-Fei Chen, Jinxi Lin, Wen-Jun Xue, Jun-Fang Zhang, Yun-Cheng Wu, Songdi Wu, Yongjun Wang, Xin-Sheng Han, Xingquan Zhao, Bin-Bin Song, Yuesong Pan, Xia Meng, Yilong Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty China chemistry.chemical_element 030204 cardiovascular system & hematology Calcium Logistic regression Brain Ischemia 03 medical and health sciences 0302 clinical medicine Modified Rankin Scale Risk Factors Internal medicine Medicine Humans cardiovascular diseases Myocardial infarction Registries Stroke Ischemic Stroke business.industry Albumin medicine.disease Prognosis 030104 developmental biology Quartile chemistry Ischemic stroke Cardiology Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Atherosclerosis. 325 |
| ISSN: | 1879-1484 |
| Popis: | Serum calcium abnormality is associated with adverse cardiovascular outcomes, but the effects of serum calcium level on stroke outcomes remain unknown. We aimed to assess the relationship between serum calcium level and 1-year outcomes in patients with acute ischemic stroke and transient ischemic attack.We included 9375 stroke patients from the China National Stroke Registry III for analysis. Participants were divided into 4 groups according to albumin corrected-calcium quartiles. Composite end point comprised recurrent stroke, myocardial infarction, other ischemic vascular events, and all-cause mortality. Multivariable Cox or logistic regression was used to evaluate the independent association of albumin corrected-calcium with all-cause mortality, recurrent stroke, composite end point, and poor functional outcome (modified Rankin Scale score ≥3).Compared with the lowest calcium quartile (2.16 mmol/L), the adjusted hazard ratio (95% CI) of the top quartile (≥2.31 mmol/L) was 1.56 (1.11-2.18) for all-cause mortality, 1.06 (0.87-1.28) for recurrent stroke and 1.08 (0.90-1.01) for composite end point, and the adjusted odds ratio for poor functional outcome was 1.18 (0.96-1.44). The addition of serum calcium to conventional risk factors improved risk prediction of all-cause mortality, leading to a small but significant increase in C-statistics and reclassification with non-significant integrated discrimination improvement (C-statistics, p = 0.02; net reclassification index 11.8%, p = 0.038; integrated discrimination improvement 0.08%, p = 0.42).High serum calcium levels at baseline were associated with all-cause mortality at 1-year after ischemic stroke, suggesting that serum calcium may be a potential prognostic biomarker and therapeutic target for ischemic stroke. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect