IL-7 activates alpha4beta1 integrin in murine thymocytes
| Autor: | Kitazawa H, Muegge K, Badolato R, Jm, Wang, We, Fogler, Dk, Ferris, Ck, Lee, Candéias S, Smith MR, Jj, Oppenheim, scott durum |
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| Přispěvatelé: | East China Sea Environmental Monitoring Center, Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Candéias, Serge |
| Rok vydání: | 1997 |
| Předmět: |
Integrins
Immunology Receptors Lymphocyte Homing Thymus Gland [SDV.BC]Life Sciences [q-bio]/Cellular Biology [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] Integrin alpha4beta1 Epithelium Mice T-Lymphocyte Subsets [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] Cell Adhesion Animals Immunology and Allergy Enzyme Inhibitors Phosphorylation [SDV.BC] Life Sciences [q-bio]/Cellular Biology Interleukin-7 Epithelial Cells Genistein Isoflavones Extracellular Matrix Fibronectins Mice Inbred C57BL [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology [SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology Protein Processing Post-Translational |
| Zdroj: | Journal of Immunology Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 1997, 159 (5), pp.2259-64 Journal of Immunology, 1997, 159 (5), pp.2259-64 Europe PubMed Central |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | IL-7, a cytokine produced by thymic epithelium, was shown to induce adhesion of murine thymocytes to gelatin-coated membranes. A major binding component of gelatin was identified as fibronectin. IL-7-induced adhesion was observed for all of the major thymocyte subsets, including double-negative, double-positive, and single-positive cells, and specific IL-7R were verified on each subset. Fibronectin binding was mediated via alpha4beta1 integrin (VLA-4), which is expressed at high levels on thymocytes. VLA-4 surface expression was not increased following IL-7 treatment, but was shown to undergo rapid tyrosine phosphorylation on the beta1 subunit. This tyrosine phosphorylation was blocked by genistein, which also blocked IL-7-induced adhesion. IL-7 was detected on the extracellular matrix of the thymus, suggesting that it could promote matrix association through an integrin pathway. |
| Databáze: | OpenAIRE |
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