Behavioral and Neurochemical Effects of Alpha-Lipoic Acid in the Model of Parkinson’s Disease Induced by Unilateral Stereotaxic Injection of 6-Ohda in Rat
| Autor: | Francisca Taciana Sousa Rodrigues, Sarah de Souza Escudeiro, Manoel Cláudio Azevedo Patrocínio, Glauce Socorro de Barros Viana, Nicole Brito Cortez Lima, Paulo Victor Pontes Araújo, Carlos Eduardo de Souza Menezes, Dayane Pessoa de Araújo, Silvânia Maria Mendes Vasconcelos, Caren Nádia Soares de Sousa, Lissiana Magna Vasconcelos Aguiar |
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| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty Parkinson's disease Article Subject Pharmacology medicine.disease_cause Open field Lipid peroxidation chemistry.chemical_compound Neurochemical TBARS medicine Ratos business.industry Dopaminergic lcsh:Other systems of medicine lcsh:RZ201-999 medicine.disease Apomorphine Complementary and alternative medicine chemistry lipids (amino acids peptides and proteins) Doença de Parkinson business Oxidative stress Research Article medicine.drug |
| Zdroj: | Repositório Institucional da Universidade Federal do Ceará (UFC) Universidade Federal do Ceará (UFC) instacron:UFC Evidence-based Complementary and Alternative Medicine : eCAM Evidence-Based Complementary and Alternative Medicine, Vol 2013 (2013) |
| ISSN: | 1741-4288 1741-427X |
| DOI: | 10.1155/2013/571378 |
| Popis: | This study aimed to investigate behavioral and neurochemical effects ofα-lipoic acid (100 mg/kg or 200 mg/kg) alone or associated with L-DOPA using an animal model of Parkinson’s disease induced by stereotaxic injection of 6-hydroxydopamine (6-OHDA) in rat striatum. Motor behavior was assessed by monitoring body rotations induced by apomorphine, open field test and cylinder test. Oxidative stress was accessed by determination of lipid peroxidation using the TBARS method, concentration of nitrite and evaluation of catalase activity.α-Lipoic acid decreased body rotations induced by apomorphine, as well as caused an improvement in motor performance by increasing locomotor activity in the open field test and use of contralateral paw (in the opposite side of the lesion produced by 6-OHDA) at cylinder test.α-lipoic acid showed antioxidant effects, decreasing lipid peroxidation and nitrite levels and interacting with antioxidant system by decreasing of endogenous catalase activity. Therefore,α-lipoic acid prevented the damage induced by 6-OHDA or by chronic use of L-DOPA in dopaminergic neurons, suggesting thatα-lipoic could be a new therapeutic target for Parkinson's disease prevention and treatment. |
| Databáze: | OpenAIRE |
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