Clonal Production and Organization of Inhibitory Interneurons in the Neocortex
| Autor: | Keith N. Brown, Dieter Saur, Kun Huang, She Chen, Alejandro Lopez-Cruz, Chun-hui Lu, Stewart A. Anderson, Xin Tan, Xin-Jun Zhang, Zhi Han, Song-Hai Shi, Liya Ding |
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| Rok vydání: | 2011 |
| Předmět: |
Telencephalon
genetic structures Neurogenesis Mitosis Neural Inhibition Neocortex Biology Inhibitory postsynaptic potential Article Mice Neurochemical Neural Stem Cells Cell Movement Interneurons medicine Animals Cell Lineage Gene Knock-In Techniques Progenitor cell Multidisciplinary Cerebrum musculoskeletal neural and ocular physiology fungi Anatomy Preoptic Area Clone Cells medicine.anatomical_structure nervous system Excitatory postsynaptic potential Neuroglia Neuroscience |
| Zdroj: | Science. 334:480-486 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1208884 |
| Popis: | The neocortex contains excitatory neurons and inhibitory interneurons. Clones of neocortical excitatory neurons originating from the same progenitor cell are spatially organized and contribute to the formation of functional microcircuits. In contrast, relatively little is known about the production and organization of neocortical inhibitory interneurons. We found that neocortical inhibitory interneurons were produced as spatially organized clonal units in the developing ventral telencephalon. Furthermore, clonally related interneurons did not randomly disperse but formed spatially isolated clusters in the neocortex. Individual clonal clusters consisting of interneurons expressing the same or distinct neurochemical markers exhibited clear vertical or horizontal organization. These results suggest that the lineage relationship plays a pivotal role in the organization of inhibitory interneurons in the neocortex. |
| Databáze: | OpenAIRE |
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