Effect of Shortening the Scan Duration on Quantitative Accuracy of [18F]Flortaucipir Studies
| Autor: | Rik Ossenkoppele, Ronald Boellaard, Hayel Tuncel, Bart N.M. van Berckel, Tessa Timmers, Emma E. Wolters, Maqsood Yaqub, Denise Visser, Wiesje M. van der Flier, Sandeep S.V. Golla |
|---|---|
| Přispěvatelé: | Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Neurodegeneration, Neurology, APH - Personalized Medicine, APH - Methodology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
education.field_of_study medicine.diagnostic_test business.industry Population Binding potential Repeatability Quantitative accuracy 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Oncology Sampling (signal processing) Duration (music) Positron emission tomography medicine Radiology Nuclear Medicine and imaging education Nuclear medicine business 030217 neurology & neurosurgery Mathematics Interpolation |
| Zdroj: | Molecular Imaging and Biology, 23(4), 604-613. Springer New York Tuncel, H, Visser, D, Yaqub, M, Timmers, T, Wolters, E E, Ossenkoppele, R, van der Flier, W M, van Berckel, B N M, Boellaard, R & Golla, S S V 2021, ' Effect of Shortening the Scan Duration on Quantitative Accuracy of [18F]Flortaucipir Studies ', Molecular Imaging and Biology, vol. 23, no. 4, pp. 604-613 . https://doi.org/10.1007/s11307-021-01581-5 |
| ISSN: | 1536-1632 |
| Popis: | Purpose Dynamic positron emission tomography (PET) protocols allow for accurate quantification of [18F]flortaucipir-specific binding. However, dynamic acquisitions can be challenging given the long required scan duration of 130 min. The current study assessed the effect of shorter scan protocols for [18F]flortaucipir on its quantitative accuracy. Procedures Two study cohorts with Alzheimer’s disease (AD) patients and healthy controls (HC) were included. All subjects underwent a 130-min dynamic [18F]flortaucipir PET scan consisting of two parts (0–60/80–130 min) post-injection. Arterial sampling was acquired during scanning of the first cohort only. For the second cohort, a second PET scan was acquired within 1–4 weeks of the first PET scan to assess test-retest repeatability (TRT). Three alternative time intervals were explored for the second part of the scan: 80–120, 80–110 and 80–100 min. Furthermore, the first part of the scan was also varied: 0–50, 0–40 and 0–30 min time intervals were assessed. The gap in the reference TACs was interpolated using four different interpolation methods: population-based input function 2T4k_VB (POP-IP_2T4k_VB), cubic, linear and exponential. Regional binding potential (BPND) and relative tracer delivery (R1) values estimated using simplified reference tissue model (SRTM) and/or receptor parametric mapping (RPM). The different scan protocols were compared to the respective values estimated using the original scan acquisition. In addition, TRT of the RPM BPND and R1 values estimated using the optimal shortest scan duration was also assessed. Results RPM BPND and R1 obtained using 0–30/80–100 min scan and POP-IP_2T4k_VB reference region interpolation had an excellent correlation with the respective parametric values estimated using the original scan duration (r2 > 0.95). The TRT of RPM BPND and R1 using the shortest scan duration was − 1 ± 5 % and − 1 ± 6 % respectively. Conclusions This study demonstrated that [18F]flortaucipir PET scan can be acquired with sufficient quantitative accuracy using only 50 min of dual-time-window scanning time. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink