Mortality in patients with rheumatoid arthritis: a 15-year prospective cohort study
| Autor: | Michael T. Nurmohamed, G.J. Tijhuis, Leo D. Roorda, J. A. R. Van Den Hoek, Hendriek C. Boshuizen, Jacqueline M. Dekker, G.A.M. van den Bos |
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| Přispěvatelé: | APH - Health Behaviors & Chronic Diseases, Dermatology, AII - Inflammatory diseases, APH - Aging & Later Life, ACS - Atherosclerosis & ischemic syndromes, Public and occupational health |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Survival Respiratory Tract Diseases Immunology Population Cause of death Comorbidity Arthritis Rheumatoid Cohort Studies 03 medical and health sciences symbols.namesake 0302 clinical medicine Rheumatology medicine Humans Immunology and Allergy Outpatient clinic Prospective Studies 030212 general & internal medicine Poisson regression Mortality Rheumatoid arthritis Prospective cohort study education Aged VLAG Human Nutrition & Health 030203 arthritis & rheumatology education.field_of_study business.industry Longitudinal studies Humane Voeding & Gezondheid Middle Aged medicine.disease Standardized mortality ratio Cardiovascular Diseases symbols Female Epidemiology of RMD Cohort study business |
| Zdroj: | Rheumatology International, 37(4), 487-493. Springer Verlag van den Hoek, J, Boshuizen, H C, Roorda, L D, Tijhuis, G J, Nurmohamed, M T, van den Bos, G A M & Dekker, J 2017, ' Mortality in patients with rheumatoid arthritis : a 15-year prospective cohort study ', Rheumatology International, vol. 37, no. 4, pp. 487-493 . https://doi.org/10.1007/s00296-016-3638-5 Rheumatology International, 37(4), 487-493 Rheumatology international, 37(4), 487-493. Springer Verlag Rheumatology International 37 (2017) 4 Rheumatology International |
| ISSN: | 0172-8172 |
| Popis: | The aim of this study was to investigate (a) the mortality in a clinical cohort of patients with established rheumatoid arthritis in comparison with the general Dutch population over 15 years, (b) the trend in the mortality ratio during the study period, and (c) causes of death and compare these with the general population. In 1997, a sample of 1222 patients was randomly selected from the register of a large rheumatology outpatient clinic. Their mortality and primary causes of death between 1997 and 2012 were obtained from Statistics Netherlands. The standardized mortality ratio (SMR) for all-cause mortality and the number of life-years lost in the study period, adjusted for age, sex, and calendar year, were calculated. A linear poisson regression analysis was performed to evaluate change in all-cause SMR over time. Finally, the SMRs for cause-specific mortality were calculated. The mean age of the population at baseline was 60.4 (SD 15.4) years, and 72.6% of the patients were women. The estimated SMR (95% CI) for all-cause mortality was 1.54 (1.41, 1.67) with about one life-year lost over the study period. There was a trend to decreasing SMR (2% annually, p = .07). Mortality was higher compared with the general population for circulatory system diseases, respiratory system diseases, musculoskeletal system diseases, and digestive system diseases (p < .05). The observed mortality among patients with RA was 54% higher than in the general population after adjustment for age, sex and calendar year. More than one life-year was lost over 15 years, and the mortality tended to decrease over time. The mortality was higher for cardiovascular, respiratory, musculoskeletal and digestive diseases. |
| Databáze: | OpenAIRE |
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