Improvement of post platelet transfusion increments following intravenous immunoglobulin therapy for leukaemic HLA-immunized patients
| Autor: | R.J. Crawford, J. Gribben, T. Sheehan, G.P. Sandilands, H. I. Atrah, J. R. O'Donnel |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Lymphocyte Immunoglobulins Platelet Transfusion Human leukocyte antigen Immunoglobulin E Intravenous Immunoglobulin Therapy HLA Antigens medicine Humans Blood Transfusion Platelet Aged biology business.industry Hematology medicine.disease Hodgkin Disease Leukemia Myeloid Acute Leukemia Platelet transfusion medicine.anatomical_structure Immunology biology.protein Immunotherapy Antibody business |
| Zdroj: | Scandinavian Journal of Haematology. 36:160-164 |
| ISSN: | 0036-553X |
| Popis: | 3 patients with acute leukaemia, HLA antibodies and thrombocytopenia refractory to random donor platelet transfusions were treated with high-dose i.v. immunoglobulin. All 3 patients responded favourably with improved post-transfusion recovery of random platelets. In 1 patient, the recovery of transfused histocompatible platelets was also enhanced. Treatment was followed by reduction in the total lymphocyte count and marked changes in lymphocyte subsets in 1 patient. |
| Databáze: | OpenAIRE |
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