Hepatitis B virus deoxyribonucleic acid in serum during hepatitis B e antigen clearance in corticosteroid-treated severe chronic active hepatitis B
| Autor: | Jorge Rakela, Robert C. Chase, Howard F. Taswell, James R. Wood, Jurgen Ludwig, Albert J. Czaja |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Hepatitis b e antigen Hepatitis B virus Aspartate aminotransferase activity medicine.drug_class medicine.disease_cause Adrenal Cortex Hormones Azathioprine Humans Medicine Hepatitis B e Antigens Hepatitis Chronic Hepatitis Hepatology business.industry Chronic Active Gastroenterology Hepatitis B virus deoxyribonucleic acid Middle Aged Hepatitis B medicine.disease Virology DNA Viral Chronic active hepatitis B Prednisone Corticosteroid Drug Therapy Combination business Follow-Up Studies |
| Zdroj: | Gastroenterology. 93:1225-1230 |
| ISSN: | 0016-5085 |
| Popis: | The relationship between hepatitis B virus deoxyri-bonucleic acid in serum and histologic activity was determined in 11 patients with corticosteroid-treated severe chronic active hepatitis B who underwent clearance of hepatitis B e antigen. All patients cleared hepatitis B virus deoxyribonucleic acid from the serum, and clearance preceded the loss of hepatitis B e antigen by 9–49 mo (mean 24 ± 4 mo). Seropositivity for hepatitis B virus deoxyribonucleic acid was always associated with histologic features of chronic active hepatitis. Resolution of histologic activity followed the loss of hepatitis B virus deoxyribonucleic acid from the serum and it preceded clearance of hepatitis B e antigen in all patients. A transient elevation of serum aspartate aminotransferase activity occurred in 5 patients at the time that absence of hepatitis B virus deoxyribonucleic acid in serum was first demonstrated, and it was followed by resolution of histologic activity. The serum level of hepatitis B virus deoxyribonucleic acid slowly decreased or remained unchanged in all but 1 patient during long-term corticosteroid therapy. We conclude that hepatitis B virus deoxyribonucleic acid in serum is associated with histologic activity in corticosteroid-treated patients with severe chronic active hepatitis B. Disappearance of hepatitis B virus deoxyribonucleic acid from the serum precedes the loss of histologic activity and clearance of hepatitis B e antigen. Serum hepatitis B virus deoxyribonucleic acid levels usually do not increase during long-term corticosteroid therapy. |
| Databáze: | OpenAIRE |
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