Tryptophan and Kynurenine Metabolites: Are They Related to Depression?
| Autor: | Franco Montebovi, Maria Elena Seretti, Denise Erbuto, Maurizio Simmaco, Luana Lionetto, Paolo Girardi, Mario Amore, Isabella Berardelli, Marco Innamorati, Gianluca Serafini, Alberto Forte, Martina Curto, Ross J. Baldessarini, Maurizio Pompili |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Serotonin medicine.medical_specialty Xanthurenates Bipolar Disorder Suicide Attempted Depression Kynurenine Suicide Tryptophan 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Medicine Humans Xanthurenic acid ortho-Aminobenzoates Bipolar disorder Biological Psychiatry Depressive Disorder Major Suicide attempt business.industry Hydroxyindoleacetic Acid medicine.disease 030227 psychiatry Psychiatry and Mental health Neuropsychology and Physiological Psychology Endocrinology chemistry Case-Control Studies Female Major depressive disorder Serotonin Production business 030217 neurology & neurosurgery |
| Zdroj: | Neuropsychobiology. 77(1) |
| ISSN: | 1423-0224 |
| Popis: | Background: Some previous studies found decreased concentrations of L-tryptophan (TRY) and increased L-kynurenine (KYN), or its metabolites, in the body fluids of subjects with major depressive disorder (MDD), sometimes in association with suicidal behavior. Such changes might indicate a shift of TRY away from serotonin production, possibly via the effects of inflammatory peptides which activate indoleamine-2,3-dioxygenase. However, these findings have been inconsistent and require replication. Methods: We used sensitive liquid-chromatography mass spectrometry methods to assay plasma concentrations of TRY, 5-hydroxyindoleacetic acid (5-HIAA), and KYN and its metabolites (anthranilic acid and xanthurenic acid). We compared 49 hospitalized, depressed subjects diagnosed with MDD (n = 37) or bipolar disorder (BD, n = 12), with (n = 22) or without (n = 27) previous suicide attempts, to 78 healthy, ambulatory controls of similar age and sex (total n = 127). Findings: Contrary to expectation, TRY plasma concentrations were higher, KYN plasma concentrations were lower, and their ratio much higher in depressed subjects, with no relationship to suicidal history. Concentrations of 5-HIAA and the kynurenine metabolites did not differ between depressed and healthy subjects. Conclusions: These findings are opposite to expectations and not consistent with a hypothesized increased conversion from TRY to KYN in depressed subjects. In addition, we found no evidence of altered production of serotonin as 5-HIAA concentration was unchanged. None of the observed changes was associated with a history of suicide attempt. |
| Databáze: | OpenAIRE |
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