Temporal factors alter effects of social housing conditions on responses to chemotherapy and hormone levels in a Shionogi mammary tumor model
| Autor: | Leslie R. Kerr, Joanne T. Emerman, Joanne Weinberg, Heather N. Andrews, Karen S. Strange |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Tumor cells Antineoplastic Agents Mice Inbred Strains Growth hormone chemistry.chemical_compound Mice Random Allocation Corticosterone Internal medicine medicine Animals Testosterone Applied Psychology Chemotherapy Mammary tumor business.industry Mammary Neoplasms Experimental Housing Animal Psychiatry and Mental health Endocrinology chemistry Growth Hormone business Post-chemotherapy Stress Psychological Hormone |
| Zdroj: | Psychosomatic medicine. 68(6) |
| ISSN: | 1534-7796 |
| Popis: | OBJECTIVE To identify possible hormonal factors involved in the differential responses to chemotherapy observed in our tumor model, we investigated if the timing among tumor cell injection, rehousing, and chemotherapy administration differentially affects levels of corticosterone (CORT), growth hormone (GH), and testosterone and tumor and host responses to chemotherapy. METHODS Mice were reared either individually (I) or in groups (G). At 2 to 4 months, mice were injected with tumor cells and retained in their original housing conditions or rehoused into different experimental groups (GG, IG, II, GI) either immediately (experiment 1) or 14 days later (experiment 2); chemotherapy was administered when tumors weighed approximately 0.8 g. RESULTS In experiment 1, IG and GG mice had better responses to chemotherapy than GI mice. Chemotherapy increased CORT levels in II mice and decreased GH levels in GI mice compared with those of their drug vehicle-treated counterparts. Under the temporal conditions of experiment 2, IG and GG mice lost the advantage seen in experiment 1 in terms of tumor and host responses to chemotherapy. Before chemotherapy administration, CORT levels in IG mice and GH levels in GI mice were higher than those in mice in all other housing conditions. At 1 day after chemotherapy, CORT levels were higher for chemotherapy-treated than for drug vehicle-treated IG mice, and at 5 days post chemotherapy, GH levels were higher in GI than in IG mice. CONCLUSIONS Temporal relationships among tumor cell injection, rehousing, and chemotherapy administration critically influence responses to chemotherapy; these effects may be mediated, in part, by alterations in hormone levels. |
| Databáze: | OpenAIRE |
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