Combined Endothelialization Promoting and Surface Binding Chimeric Conjugate with Low Thrombogenicity
| Autor: | Avneesh Chopra, Franziska Schmidt, Matthias Gabriel |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood Platelets
Phage display Surface Properties Biomedical Engineering Pharmaceutical Science Thrombogenicity Bioengineering 02 engineering and technology Polyethylene glycol 01 natural sciences Cell Line Polyethylene Glycols chemistry.chemical_compound Restenosis Coated Materials Biocompatible PEG ratio medicine Cell Adhesion Humans Pharmacology Titanium 010405 organic chemistry Chemistry Organic Chemistry Thrombosis 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Endothelial stem cell Silanization Stents Endothelium Vascular 0210 nano-technology Peptides Biotechnology Conjugate Biomedical engineering |
| Zdroj: | Bioconjugate chemistry. 32(8) |
| ISSN: | 1520-4812 |
| Popis: | Endothelialization of blood contacting implants, e.g., vascular stents, is regarded as a prerequisite for an improved performance in terms of minimizing thrombogenicity and the inhibition of restenosis. Commonly used materials, such as Ti-based alloys, can be surface-modified in order to improve endothelial cell (EC) colonization as well as to reduce platelet adhesion. Standard modification techniques involve silanization and are laborious and time-consuming. We propose a novel single-step procedure based on a surface-recognizing peptide generated by phage display methodology. Combining this with a polyethylene glycol (PEG) spacer and an EC-specific sequence yielded a conjugate applicable for the modification of Ti surfaces. |
| Databáze: | OpenAIRE |
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