Experimental Autoimmune Encephalomyelitis Develops in CC Chemokine Receptor 7-deficient Mice with Altered T-cell Responses
| Autor: | Peter Hevezi, Sandra M. Lechner, Anil Pahuja, A. Chen, Richard B. Roth, David G. Alleva, Albert Zlotnik, Gail M. Verge, Richard A. Maki |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Receptors CCR7 Encephalomyelitis Autoimmune Experimental T cell Lymphocyte Molecular Sequence Data Immunology chemical and pharmacologic phenomena Spleen C-C chemokine receptor type 7 Immunophenotyping Myelin oligodendrocyte glycoprotein Mice Immune system Cell Movement T-Lymphocyte Subsets immune system diseases medicine Animals Amino Acid Sequence Cells Cultured Mice Knockout biology Experimental autoimmune encephalomyelitis hemic and immune systems Dendritic Cells General Medicine medicine.disease Mice Inbred C57BL medicine.anatomical_structure Chemokines CC Chronic Disease biology.protein Female Receptors Chemokine Lymph Nodes CC chemokine receptors |
| Zdroj: | Scandinavian Journal of Immunology. 64:361-369 |
| ISSN: | 1365-3083 0300-9475 |
| DOI: | 10.1111/j.1365-3083.2006.01787.x |
| Popis: | CC chemokine receptor 7 (CCR7) is involved in the initiation of immune responses by mediating the migration of naive T cells and mature dendritic cells to T-cell-rich zones of secondary lymphoid organs where antigen presen- tation occurs. To address whether CCR7 plays a role in the development of autoimmunity, we induced experimental autoimmune encephalomyelitis in CCR7-deficient mice on a C57BL/6 background (CCR7 )/) ) using the neuroan- tigen, myelin oligodendrocyte glycoprotein 35-55 amino acid peptide (MOG(35)55)) and Bordetella pertussis toxin (PTX). CCR7 )/) mice acquired dis- ease with an intensity similar to wild-type littermates. MOG(35)55)-specific lymphocyte responses were dominant in the spleen of CCR7 )/) mice, rather than in lymph nodes as observed in wild-type mice. These results indicate that effective immune responses (with altered kinetics) can develop in the absence of CCR7 but develop in the spleen rather than lymph nodes as CCR7 is neces- sary for T and dendritic cells to enter lymph nodes. |
| Databáze: | OpenAIRE |
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