Pro-neurotensin/Neuromedin N and Hypertension Risk: A Prospective Study
Autor: | George Howard, Janin Schulte, Mary Cushman, D L Long, Charles D Nicoli, Timothy B Plante, Suzanne E. Judd |
---|---|
Rok vydání: | 2021 |
Předmět: |
Adult
medicine.medical_specialty Original Contributions Rate ratio chemistry.chemical_compound Risk Factors Interquartile range Internal medicine Internal Medicine medicine Humans Prospective Studies Prospective cohort study Stroke Neurotensin business.industry Neuropeptides medicine.disease Peptide Fragments Blood pressure chemistry Hypertension Cardiology Neuromedin N business Cohort study |
Zdroj: | Am J Hypertens |
ISSN: | 1941-7225 0895-7061 |
Popis: | Background Neurotensin, a neuropeptide with direct cardiac effects, has been associated with prospective risk of hypertension-related conditions through measurement of its precursor, pro-neurotensin/neuromedin N (pro-NT/NMN). Its association with incident hypertension has not been evaluated. Methods From 2003 to 2007, the REasons for Geographic And Racial Differences in Stroke (REGARDS) study enrolled 30,239 Black or White adults age ≥45. Pro-NT/NMN was measured in 1,692 participants without baseline hypertension (self-reported antihypertensive use or blood pressure ≥140/90 mm Hg) who underwent follow-up assessment in 2013–2016. A sensitivity analysis was conducted using a lower threshold (≥130/80 mm Hg) to define hypertension. Three robust Poisson regression models were fitted to risk of incident hypertension, adding demographics, cardiometabolic risk factors, and dietary covariates. Results Six hundred and fourteen participants developed hypertension over 9.4 years of follow-up. Pro-NT/NMN ranged from 14 to 1,246 pmol/l, with median [interquartile range] 154 [112, 206] pmol/l. Pro-NT/NMN was not associated with hypertension overall (fully adjusted incidence rate ratio per SD increment log pro-NT/NMN 1.03, 95% confidence interval 0.95–1.11). Results of sensitivity analysis did not differ substantially. Conclusions Baseline pro-NT/NMN was not associated with incident hypertension. This may be a result of neurotensin’s long-term interactions with other molecular regulators of blood pressure, such as the renin–angiotensin–aldosterone system. |
Databáze: | OpenAIRE |
Externí odkaz: |