In vivo phosphorus NMR spectroscopy of skin using a crossover surface coil
| Autor: | Steen Rg, Izenberg S, James A. Nelson, Todd L. Richards, Yuhchyau Chen, Robert N. Golden, Williams Dl |
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| Rok vydání: | 1992 |
| Předmět: |
Models
Anatomic Magnetic Resonance Spectroscopy Phosphocreatine Dermatologic Surgical Procedures Surgical Flaps Imaging phantom Phosphates chemistry.chemical_compound Organophosphorus Compounds Nuclear magnetic resonance Ischemia In vivo Surface coil Animals Radiology Nuclear Medicine and imaging Phosphorus-31 NMR spectroscopy Spectroscopy Skin Tissue Survival integumentary system Phosphorus Rats Inbred Strains Equipment Design Penetration (firestop) Image Enhancement Rats Inbred F344 Rats chemistry Female Nucleoside Hydrogen |
| Zdroj: | Magnetic Resonance in Medicine. 23:46-54 |
| ISSN: | 1522-2594 0740-3194 |
| DOI: | 10.1002/mrm.1910230107 |
| Popis: | A modified crossover surface coil with minimal B1 field penetration was used for collection of skin phosphorus NMR spectra. Projection imaging experiments show that the coilsensitive volume is uniform at the phosphorus frequency, but strikingly nonuniform at s the proton frequency. Experiments with an in vitro phosphorus phantom, designed to simulate skin and underlying tissue, demonstrated that 45.1% (±1.2%) of total signal was derived from Sprague-Dawley rat skin and 19.3% (±1.4%) of total signal was derived from Fischer-344 rat skin. 31P MR spectra of rat skin in vivo permitted resolution of four phosphorus compounds: nucleoside triphosphates, phosphocreatine (PCr), inorganic phosphate (Pi), and phosphomonoester. Spectra collected after skin flap surgery in Fischer-344 rats showed a 50.1% (±7.6%) reduction in the ratio of PCr/Pi within 30 min of surgery, compared to presurgical PCr/Pi levels (P < 0.01). Skin phosphorus spectra are potentially useful for assessment of skin flap and skin graft viability. © 1992 Academic Press, Inc. |
| Databáze: | OpenAIRE |
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