Severe Combined Immunodeficiency: Otolaryngological Presentation and Management
| Autor: | Sheila Kun, Erin Simms, Joseph A. Church, Rose Mary S. Stocks, Jerome W. Thompson |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Mastoiditis medicine.medical_specialty Pediatrics 03 medical and health sciences 0302 clinical medicine Humans Medicine 030223 otorhinolaryngology Abscess Mouth ulcers Oral Ulcer Recurrent upper respiratory tract infections Immunodeficiency Retrospective Studies biology business.industry Infant Pharyngitis Genetic Therapy General Medicine biology.organism_classification medicine.disease Surgery Pneumocystis Infections Otitis Media Otitis Cough Otorhinolaryngology 030220 oncology & carcinogenesis Female Severe Combined Immunodeficiency medicine.symptom Lung Diseases Interstitial business Thrush Neck |
| Zdroj: | Annals of Otology, Rhinology & Laryngology. 108:403-407 |
| ISSN: | 1943-572X 0003-4894 |
| DOI: | 10.1177/000348949910800415 |
| Popis: | In order to increase the awareness of otolaryngologists of severe combined immunodeficiency syndrome (SCIDS) so they may contribute to an earlier diagnosis of this disorder, we performed a retrospective chart review of a multicenter series from 2 children's hospital medical centers. Eighteen cases were identified, and 14 had an otolaryngological presentation. The average age of presentation was 3.3 months, and 72% were males. Most cases were inherited in an X-linked fashion. Five patients had thrush; 4 had recurrent otitis media. Other otolaryngological presentations included cough, mouth ulcers, pharyngitis, mastoiditis, and bilateral neck abscess. The most severe form of immunodeficiency, SCIDS is a rare condition that involves a disorder in both T and B cell functions. The manifestations involving the head and neck include recurrent upper respiratory tract infections, otitis media, thrush, oral ulcers, and abscesses. It is important that SCIDS be considered in any infant with recurrences of these common infections. |
| Databáze: | OpenAIRE |
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