The effect of free glycerol intake on cerebral glycerol concentration
| Autor: | Jiřina Habalová, Pavel Poczos, P Travnicek, Martin Kanta, J Mejzlik, T Cesak, J Adamkov, M Bartos |
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| Rok vydání: | 2021 |
| Předmět: |
Glycerol
Economics and Econometrics medicine.medical_specialty Free Glycerol Microdialysis Subarachnoid hemorrhage Hemorragia subaracnoidea Brain Forestry Subarachnoid Hemorrhage medicine.disease chemistry.chemical_compound Endocrinology Cerebral microdialysis chemistry Brain concentrations Internal medicine Materials Chemistry Media Technology medicine Humans In patient Retrospective Studies |
| Zdroj: | Bratislava Medical Journal. 122:24-27 |
| ISSN: | 1336-0345 |
| DOI: | 10.4149/bll_2021_032 |
| Popis: | Objective Cerebral microdialysis (CMD) is a method used to measure the concentration of metabolites and glycerol in the interstitium of the brain. The aim of this study was to investigate the effect of parenterally applied medication and nutrition containing external free glycerol (EFG) on cerebral values of glycerol in patients monitored and treated for non-traumatic subarachnoid hemorrhage (SAH). Methods In 13 patients, the values of CG concentrations were measured using CMD. The amounts of parenterally applied EFG (in hourly intervals) were calculated from patient records. All data were gathered retrospectively. To analyze the association between the parameters of interest and their relationship, Spearman´s correlation and p-values were calculated. Results There was no evident relationship between the CG and EFG concentrations when the dataset was analyzed as a whole (r = -0.146). However, when the analysis was applied to single patients, a varying degree of correlations was discovered in 7 patients (r = 0.431-0.867). Conclusion The possible effect of externally administered glycerol contained in pharmaceuticals and nutrition on its brain concentrations must be considered when interpreting data of CMD (Tab. 2, Fig. 4,Ref. 16) Keywords: glycerol, microdialysis, brain, subarachnoid hemorrhage. |
| Databáze: | OpenAIRE |
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