Diversity-Oriented Synthesis as a Tool for Chemical Genetics
| Autor: | Antonio Guarna, Elena Lenci, Andrea Trabocchi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
media_common.quotation_subject
High-throughput screening Molecular Conformation Chemical biology Pharmaceutical Science Compound management chemical biology Review Computational biology Biology high-throughput screening Analytical Chemistry Small Molecule Libraries lcsh:QD241-441 lcsh:Organic chemistry Drug Discovery Physical and Theoretical Chemistry media_common Drug discovery Organic Chemistry Combinatorial chemistry Small molecule small molecules chemical genetics Models Chemical Pharmacogenetics Chemistry (miscellaneous) Drug Design Chemical diversity Molecular Medicine diversity-oriented synthesis human activities Chemical genetics Diversity (politics) |
| Zdroj: | Molecules, Vol 19, Iss 10, Pp 16506-16528 (2014) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Chemical genetics is an approach for identifying small molecules with the ability to induce a biological phenotype or to interact with a particular gene product, and it is an emerging tool for lead generation in drug discovery. Accordingly, there is a need for efficient and versatile synthetic processes capable of generating complex and diverse molecular libraries, and Diversity-Oriented Synthesis (DOS) of small molecules is the concept of choice to give access to new chemotypes with high chemical diversity. In this review, the combination of chemical genetics and diversity-oriented synthesis to identify new chemotypes as hit compounds in chemical biology and drug discovery is reported, giving an overview of basic concepts and selected case studies. |
| Databáze: | OpenAIRE |
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