Virucidal activity of glutaric acid and evidence for dual mechanism of action
| Autor: | M F Kuhrt, M A McKinlay, M J Fancher, S D Lennert |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Rhinovirus
Stereochemistry Carboxylic acid Viral Plaque Assay Glutaric acid Glutarates medicine.disease_cause Medicinal chemistry Antiviral Agents chemistry.chemical_compound medicine Humans Pharmacology (medical) Pharmacology Virus quantification chemistry.chemical_classification Chemistry Drug Resistance Microbial Hydrogen-Ion Concentration In vitro Cold Temperature Infectious Diseases Mechanism of action medicine.symptom Sodium acetate HeLa Cells Research Article |
| Zdroj: | Antimicrobial agents and chemotherapy. 26(6) |
| ISSN: | 0066-4804 |
| Popis: | Rhinoviruses as a group are notably sensitive to inactivation in solutions with a pH of less than 5.3. Glutaric acid appears to possess virucidal activity in addition to the aciduant effect against rhinoviruses. A model system in which rhinovirus type 14 was incubated in the presence of glutaric acid (GA) (pH 4.0) at 0 degrees C was devised to separate intrinsic virucidal activity from the aciduant effect. Under these conditions, virucidal activity against rhinovirus type 14 was directly related to the concentration of GA present and the proportion of the acid in the diprotonated form. The virucidal activities of GA and several other compounds, including GA analogs and other mono- and dicarboxylic acids, were tested under the conditions described. In general, as the alkane bridge separating two carboxylic acid functions was lengthened, virucidal activity decreased. When 26 additional strains of rhinoviruses were tested in the model system, 19 were inactivated slowly enough to be compared. Of these, 63% were more susceptible to GA than to sodium acetate buffer and 26% were more susceptible to sodium acetate buffer. Eleven percent were resistant to both GA and sodium acetate buffer. The virucidal activity of GA for a majority of strains tested appeared to be due to combination of low pH and another mechanism of action presumably unrelated to pH. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|