PD-1 Expression and its Correlation With Prognosis in Clear Cell Renal Cell Carcinoma
| Autor: | Jong Sil Lee, Jung Wook Yang, Gyung Hyuk Ko, Ji Min Na, Min Hye Kim, Jeong-Hee Lee, Hyo Jung An, Dong Chul Kim, Dae Hyun Song |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Multivariate analysis Programmed Cell Death 1 Receptor General Biochemistry Genetics and Molecular Biology B7-H1 Antigen Correlation Internal medicine Republic of Korea Biomarkers Tumor Medicine Humans In patient Carcinoma Renal Cell Survival analysis Pharmacology Univariate analysis Tissue microarray business.industry medicine.disease University hospital Prognosis Kidney Neoplasms Clear cell renal cell carcinoma business Research Article |
| Zdroj: | In Vivo |
| Popis: | BACKGROUND/AIM Programmed death ligand-1 (PD-L1) and programmed death protein 1 (PD-1) expression levels in many tumors and their correlation with prognosis have been actively studied. However, studies on PD-1 expression and its prognostic value in clear cell renal cell carcinoma (ccRCC) are limited and controversial. In this study, we describe the expression of PD-1 and its prognostic significance and association with clinical features in patients with ccRCC. MATERIALS AND METHODS We obtained clinicopathological data from 166 patients with ccRCC who were treated at Gyeongsang National University Hospital, Jinju, Korea between January 2000 and December 2009. Tissue microarray blocks were made using representative paraffin blocks of ccRCC specimens. Two pathologists analyzed PD-L1 and PD-1 expression in both tumor and inflammatory cells. RESULTS PD-1 expression in tumor-infiltrating inflammatory cells was significantly correlated with unfavorable disease-free survival (DFS) (p |
| Databáze: | OpenAIRE |
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