Eradication of disseminated adenovirus infection in a pediatric hematopoietic stem cell transplantation recipient using the novel antiviral agent CMX001
| Autor: | Jane Sande, Tim Tippin, Margaret Anderson, Roberta L. DeBiasi, E. Randall Lanier, Terry J. Fry, Evelio Perez, Kris Paolino, Barbara Jantausch, Brett Loechelt, Wendy Painter |
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| Rok vydání: | 2010 |
| Předmět: |
viruses
medicine.medical_treatment Congenital cytomegalovirus infection Organophosphonates Brincidofovir Hematopoietic stem cell transplantation Antiviral Agents Polymerase Chain Reaction Adenovirus Infections Human chemistry.chemical_compound Cytosine Immunocompromised Host Virology medicine Humans Adenovirus infection Child business.industry Hematopoietic Stem Cell Transplantation Hematopoietic stem cell medicine.disease Infectious Diseases Graft-versus-host disease medicine.anatomical_structure chemistry Immunology Female Stem cell business medicine.drug Cidofovir |
| Zdroj: | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 50(2) |
| ISSN: | 1873-5967 |
| Popis: | Adenovirus infection is a serious and often fatal complication in hematopoietic stem cell transplant patients. There are currently no FDA-approved therapies for adenovirus infection, with only anecdotal, off-label uses described for a variety of anti-viral agents or immune therapies. We report the first case of successful eradication of disseminated adenovirus infection by the novel antiviral agent CMX001 in a severely immunocompromised pediatric stem cell transplant recipient following failure to respond to intravenous cidofovir. Complete clinical and virologic response was documented; virologic and pharmacokinetic data are reported. CMX001 is a promising new oral antiviral agent under development for the prophylaxis and treatment of severe infections caused by double-stranded DNA viruses including adenovirus in immunocompromised patients. |
| Databáze: | OpenAIRE |
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