Pharmacogenetic Interactions Between Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Response to Cibenzoline in Patients With Hypertrophic Obstructive Cardiomyopathy
| Autor: | Kazuhisa Nishimura, Akiyoshi Ogimoto, Jun Suzuki, Tetsuro Miki, Mareomi Hamada, Tomoaki Ohtsuka, Katsuji Inoue, Takayuki Nagai, Jitsuo Higaki, Hideki Okayama, Yuji Shigematsu, Makoto Saito |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Administration Oral Peptidyl-Dipeptidase A Left ventricular hypertrophy Ventricular Function Left chemistry.chemical_compound Gene Frequency Internal medicine Genotype medicine Humans Allele Pharmacology Polymorphism Genetic biology business.industry Imidazoles Hypertrophic cardiomyopathy Angiotensin-converting enzyme DNA Cardiomyopathy Hypertrophic Middle Aged medicine.disease Mutagenesis Insertional Treatment Outcome chemistry Echocardiography Pharmacogenetics Cibenzoline Ventricular pressure biology.protein Cardiology Female Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents Gene Deletion |
| Zdroj: | Journal of Cardiovascular Pharmacology. 55:506-510 |
| ISSN: | 0160-2446 |
| Popis: | Cibenzoline, a Class I antiarrhythmic agent, can attenuate the left ventricular pressure gradient (LVPG) in patients with hypertrophic obstructive cardiomyopathy (HOCM). An association between the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene and the progression of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy has been reported. The aim of this study was to investigate the pharmacogenetic interactions between the ACE insertion/deletion polymorphism and the response to cibenzoline in patients with HOCM. Twenty-four patients with HOCM participated in this study. The LVPG and left ventricular function were measured by echocardiography before and 2 hours after administration of a single oral dose of 200 mg cibenzoline. The ACE insertion/deletion polymorphism was genotyped. The frequencies of the genotypes D/D, D/I, and I/I were 16%, 42%, and 42%, respectively. Before administration of cibenzoline, the LVPG was higher in patients with the D allele than in those without it (105 +/- 47 mm Hg versus 64 +/- 24 mm Hg, P = 0.0195). After administration of cibenzoline, the LVPG significantly decreased to 41 +/- 27 mm Hg in those with the D allele (P = 0.0001) and to 33 +/- 24 mm Hg in those without it (P = 0.0003). The LVPG in patients with the D allele was significantly decreased by cibenzoline when compared with patients without the allele (64 +/- 45 mm Hg versus 31 +/- 17 mm Hg, P = 0.038). Patients with HOCM with the ACE D allele had a high LVPG. Cibenzoline was more effective in patients with HOCM with the ACE D allele. |
| Databáze: | OpenAIRE |
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