Mechanisms of Hemostimulating Effects of Granulocytic CSF and Pantohematogen under Conditions of Cytostatic Myelosuppression
| Autor: | V. E. Gol’dberg, T. Yu. Khrichkova, V. V. Shdanov, L. A. Miroshnichenko, A. M. Dygai, E. V. Udut, M. Yu. Minakova, G. N. Zyuz’kov, E. V. Simanina, L. A. Stavrova |
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| Rok vydání: | 2011 |
| Předmět: |
Neutrophils
Bone Marrow Cells General Biochemistry Genetics and Molecular Biology Biological Factors Leukocyte Count Mice Monocytosis Bone Marrow medicine Animals Cyclophosphamide Hyperplasia business.industry Regeneration (biology) Granulocyte-Macrophage Colony-Stimulating Factor General Medicine medicine.disease Neutrophilia Peripheral blood Hematopoiesis Haematopoiesis medicine.anatomical_structure Immunology Mice Inbred CBA Female Fluorouracil Bone marrow Pantohematogen medicine.symptom business |
| Zdroj: | ResearcherID |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-011-1228-9 |
| Popis: | We compared hemostimulating activity of pantohematogen and granulocytic CSF under conditions of 5-fluorouracil-induced cytostatic myelosuppression. It was found that activation of hemopoiesis regeneration under the effect of the test preparations was accompanied by the development of hyperplasia of the granulocytic and monocytic hemopoietic bone marrow lineages and more rapid recovery of the count of pholymorphonuclear leukocytes and monocytes in the peripheral blood (more marked under the effect of pantohematogen) followed by neutrophilia and monocytosis. |
| Databáze: | OpenAIRE |
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