Observations on the Ultrastructure of Platelets in Glanzmann's Disease
| Autor: | Margaret A. Howard, Sue J. Farmer, Barry G. Firkin |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Adolescent Latex Sodium chemistry.chemical_element chemistry.chemical_compound Platelet Adhesiveness Thrombasthenia Internal medicine medicine Humans Platelet Incubation Thorotrast Edetic Acid Cell Membrane Syndrome Hematology Glanzmann's disease Microspheres Blood Cell Count Microscopy Electron Endocrinology Purpura Thrombocytopenic chemistry Ultrastructure Female Thorium Dioxide |
| Zdroj: | British Journal of Haematology. 27:527-532 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.1974.tb06817.x |
| Popis: | Summary. The platelets from six patients with congenital thrombasthenia (Glanzmann's disease) have been studied with respect to their ultrastructure and to the changes which occur following incubation with 4% sodium EDTA and uptake of particulate matter in the form of thorotrast and latex following incubation at timed intervals. Platelets from all patients behaved abnormally on incubation with EDTA. Thorotrast uptake was greatly increased in three and possibly reduced in the remaining three patients. Latex uptake was normal to increased in four of the patients and greatly reduced or absent in two. These differences must reflect abnormalities in membrane properties and/or cell metabolism. These findings suggested that there are at least two varieties of Glanzmann's disease. |
| Databáze: | OpenAIRE |
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