Acute hypercortisolemia exerts depot-specific effects on abdominal and femoral adipose tissue function
| Autor: | Jeremy W. Tomlinson, Iwona J. Bujalska, Michael W O'Reilly, Konstantinos N. Manolopoulos, Wiebke Arlt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Hydrocortisone Lipolysis Endocrinology Diabetes and Metabolism Glucose uptake Clinical Biochemistry Adipose tissue 030209 endocrinology & metabolism Biochemistry Young Adult 03 medical and health sciences chemistry.chemical_compound Absorptiometry Photon 0302 clinical medicine Endocrinology NEFA Double-Blind Method Internal medicine Abdomen medicine Humans Femur Cushing Syndrome Clinical Research Articles Obesity and Adipocyte Biology Fatty acid metabolism Triglyceride business.industry Biochemistry (medical) Middle Aged Subcutaneous Fat Abdominal 3. Good health 030104 developmental biology Hypercortisolemia Adipose Tissue Thigh chemistry business Glucocorticoid medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology and Metabolism |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Context: Glucocorticoids have pleiotropic metabolic functions, and acute glucocorticoid excess affects fatty acid metabolism, increasing systemic lipolysis. Whether glucocorticoids exert adipose tissue depot-specific effects remains unclear. Objective: To provide an in vivo assessment of femoral and abdominal adipose tissue responses to acute glucocorticoid administration. Design and Outcome Measures: Nine healthy male volunteers were studied on two occasions, after a hydrocortisone infusion (0.2 mg/kg/min for 14 hours) and a saline infusion, respectively, given in randomized double-blind order. The subjects were studied in the fasting state and after a 75-g glucose drink with an in vivo assessment of femoral adipose tissue blood flow (ATBF) using radioactive xenon washout and of lipolysis and glucose uptake using the arteriovenous difference technique. In a separate study (same infusion design), eight additional healthy male subjects underwent assessment of fasting abdominal ATBF and lipolysis only. Lipolysis was assessed as the net release of nonesterified fatty acids (NEFAs) from femoral and abdominal subcutaneous adipose tissue. Results: Acute hypercortisolemia significantly increased basal and postprandial ATBF in femoral adipose tissue, but the femoral net NEFA release did not change. In abdominal adipose tissue, hypercortisolemia induced substantial increases in basal ATBF and NEFA release. Conclusions: Acute hypercortisolemia induces differential lipolysis and ATBF responses in abdominal and femoral adipose tissue, suggesting depot-specific glucocorticoid effects. Abdominal, but not femoral, adipose tissue contributes to the hypercortisolemia-induced systemic NEFA increase, with likely contributions from other adipose tissue sources and intravascular triglyceride hydrolysis. Acute experimental hypercortisolemia induces differential metabolic responses in abdominal and femoral adipose tissue in vivo, suggesting depot-specific glucocorticoid effects in humans. |
| Databáze: | OpenAIRE |
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