Expression of cyclooxygenase-2 in breast carcinogenesis and its relation to HER-2/neu and p53 protein expression in invasive ductal carcinoma
| Autor: | J.H. Yoon, Jae Hyuk Lee, M.H. Cho, Kyung-Whan Min, Y.J. Jaegal, J. H. Nam, S. Woo Juhng, Chan Choi, Chul Soon Park, Min-Cheol Lee, Ji Shin Lee, Yoo Duk Choi |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Receptor ErbB-2 Breast Neoplasms medicine.disease_cause medicine Humans Breast carcinogenesis skin and connective tissue diseases Aged Neoplasm Staging Proportional Hazards Models biology business.industry Carcinoma Ductal Breast General Medicine Middle Aged Hyperplasia Ductal carcinoma medicine.disease Invasive ductal carcinoma Immunohistochemistry Survival Analysis Gene Expression Regulation Neoplastic Cyclooxygenase 2 Disease Progression biology.protein Female Surgery Cyclooxygenase Tumor Suppressor Protein p53 Antibody Carcinogenesis business |
| Zdroj: | The Breast. 15:390-398 |
| ISSN: | 0960-9776 |
| Popis: | The purpose of this study was to evaluate cyclooxygenase-2 (COX-2) expression in the successive steps of breast carcinogenesis and to determine its correlation with HER-2/neu and p53 expression in invasive ductal carcinomas of the breast. Immunohistochemical staining with anti-COX-2 antibody was performed in normal breast tissue, usual hyperplasia, ductal carcinoma in situ, and invasive ductal carcinoma. Expression of COX-2 in invasive ductal carcinoma was correlated with immunohistochemical expression of HER-2/neu and p53 protein. COX-2 expression was found to be progressively elevated along the continuum from normal breast tissue to invasive ductal carcinoma (P0.001). COX-2 expression significantly correlated with p53 and HER-2/neu protein expression (P0.05 and P0.001). On multivariate analysis, only TNM stage and elevated COX-2 expression correlated with survival. Our results suggest that COX-2 may be involved in the carcinogenesis of the breast and may be an independent prognostic indicator in patients with invasive ductal carcinoma. HER-2/neu and p53 are likely to be involved in the regulation of COX-2 expression in invasive ductal carcinomas of the breast. |
| Databáze: | OpenAIRE |
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