Relationship between histology, development and tumorigenesis of mammary gland in female rat
| Autor: | Michal Dubovický, Dana Macejova, Eduard Ujházy, Líska J, Viktória Kissová, Stefan Polak, Julius Brtko |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty mammary gland Stromal cell Carcinogenesis Mammary gland Mammary Neoplasms Animal Review Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Epithelium histology 03 medical and health sciences Breast cancer Mammary Glands Animal Stroma Pregnancy medicine Animals Humans rat development Carcinogen General Veterinary Histology General Medicine medicine.disease Rats 030104 developmental biology medicine.anatomical_structure Cancer research Animal Science and Zoology Female Stromal Cells |
| Zdroj: | Experimental Animals |
| ISSN: | 1881-7122 1341-1357 |
| Popis: | The mammary gland is a dynamic organ that undergoes structural and functional changes associated with growth, reproduction, and post-menopausal regression. The postnatal transformations of the epithelium and stromal cells of the mammary gland may contribute to its susceptibility to carcinogenesis. The increased cancer incidence in mammary glands of humans and similarly of rodents in association with their development is believed to be partly explained by proliferative activity together with lesser degree of differentiation, but it is not completely understood how the virgin gland retains its higher susceptibility to carcinogenesis. During its developmental cycle, the mammary gland displays many of the properties associated with breast cancer. An early first full-term pregnancy may have a protective effect. Rodent models are useful for investigating potential breast carcinogens. The purpose of this review is to help recognizing histological appearance of the epithelium and the stroma of the normal mammary gland in rats, and throughout its development in relation to tumorigenic potential. |
| Databáze: | OpenAIRE |
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