Geldanamycin, a new antibiotic
| Autor: | P. A. Meulman, D.H. Peterson, R. J. Wnuk, C. Deboer |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Magnetic Resonance Spectroscopy
Chemical Phenomena Stereochemistry Chromatography Paper Infrared Rays Ultraviolet Rays Microbial Sensitivity Tests chemistry.chemical_compound Mice Drug Discovery polycyclic compounds Moiety Animals Pharmacology Chromatography biology Bacteria Ansamycin Spectrum Analysis Fungi Eukaryota Geldanamycin biology.organism_classification In vitro Streptomyces Quinone Anti-Bacterial Agents Chemistry chemistry Biochemistry Spectrophotometry Fermentation Chromatography Thin Layer Streptomyces hygroscopicus |
| Zdroj: | The Journal of antibiotics. 23(9) |
| ISSN: | 0021-8820 |
| Popis: | A new crystalline antimicrobial compound, geldanamycin, has been discovered in the culture nitrates of Streptomyces hygroscopicus var. geldanus var. nova. Geldanamycin is moderately active in vitro against protozoa, bacteria and fungi. It is also active against L-1210 and KB cells growing in culture and against the parasite Syphacia ohlevata, in vivo. The fermentation, assay, chromatography and isolation as well as its biological and chemical properties were investigated. On the basis of its physical and chemical properties, geldanamycin is a complex molecule consisting of an unsaturated moiety attached to a quinone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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