Langerin (CD207)-positive cells in leprosy: Possible implications for pathogenesis of the disease with special emphasis on dermal immunoreactivity
| Autor: | Juarez Antônio Simões Quaresma, Tinara Leila de Souza Aarão, Luciana Mota Silva, Kelly Emi Hirai, Juarez de Souza, Francisca Regina Oliveira Carneiro, Leônidas Braga Dias, Jorge Rodrigues de Sousa |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Langerin Disease Microbiology Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Antigen Antigens CD Leprosy medicine Humans Lectins C-Type Mycobacterium leprae Skin Microscopy integumentary system biology Dendritic Cells medicine.disease biology.organism_classification Immunohistochemistry 030104 developmental biology Infectious Diseases Mannose-Binding Lectins 030220 oncology & carcinogenesis Immunology biology.protein Female Brazil |
| Zdroj: | Microbial pathogenesis. 124 |
| ISSN: | 1096-1208 |
| Popis: | Leprosy is a disease caused by Mycobacterium leprae, which is characterized by two distinct poles, the tuberculoid pole and the lepromatous pole, depending on the immune response to the bacillus. Langerin-positive cells are dendritic cells that appear to play an essential role in the development of the disease. These cells are specialized in the processing and presentation of antigens, exerting an important function in the activation of the immune system. To evaluate the expression of langerin-positive cells (CD207+) in skin lesion fragments of patients with a diagnosis of M. leprae infection and to associate the expression of these cells with the polar forms of the disease. Langerin-positive cells were detected in larger numbers in lesions of patients with the tuberculoid form compared to those with the lepromatous form. The presence of a larger number of these cells in patients with the tuberculoid form suggests an important participation of langerin-positive cells, capturing antigens and favoring an effective immune response to infection with M. leprae. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect