Human Microphysiological Models of Intestinal Tissue and Gut Microbiome
| Autor: | Steven N. Steinway, Jad Saleh, Bon-Kyoung Koo, Delphine Delacour, Deok-Ho Kim |
|---|---|
| Přispěvatelé: | Johns Hopkins University (JHU) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Nervous system Cell type Histology lcsh:Biotechnology organoid [SDV]Life Sciences [q-bio] Biomedical Engineering microfluidics microbiome Bioengineering Inflammation 02 engineering and technology Review Biology organ chip 03 medical and health sciences Immune system lcsh:TP248.13-248.65 medicine Organoid Secretion Microbiome intestinal tissue microphysiological model Bioengineering and Biotechnology 021001 nanoscience & nanotechnology Intestinal epithelium 3. Good health Cell biology 030104 developmental biology medicine.anatomical_structure gut-on-a-chip medicine.symptom 0210 nano-technology Biotechnology |
| Zdroj: | Frontiers in Bioengineering and Biotechnology Frontiers in Bioengineering and Biotechnology, Frontiers, 2020, 8, ⟨10.3389/fbioe.2020.00725⟩ Frontiers in Bioengineering and Biotechnology, Vol 8 (2020) |
| ISSN: | 2296-4185 |
| Popis: | International audience; The gastrointestinal (GI) tract is a complex system responsible for nutrient absorption, digestion, secretion, and elimination of waste products that also hosts immune surveillance, the intestinal microbiome, and interfaces with the nervous system. Traditional in vitro systems cannot harness the architectural and functional complexity of the GI tract. Recent advances in organoid engineering, microfluidic organs-on-a-chip technology, and microfabrication allows us to create better in vitro models of human organs/tissues. These micro-physiological systems could integrate the numerous cell types involved in GI development and physiology, including intestinal epithelium, endothelium (vascular), nerve cells, immune cells, and their interplay/cooperativity with the microbiome. In this review, we report recent progress in developing microphysiological models of the GI systems. We also discuss how these models could be used to study normal intestinal physiology such as nutrient absorption, digestion, and secretion as well as GI infection, inflammation, cancer, and metabolism. |
| Databáze: | OpenAIRE |
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