t(14;18) Translocation: A Predictive Blood Biomarker for Follicular Lymphoma
| Autor: | Dagmar Drogan, Aurelio Barricarte, Antonia Trichopoulou, Elisabete Weiderpass, Kim Overvad, Stephanie Sungalee, Anne Tjønneland, Nathalie Jouve, Isabelle Romieu, Sandrine Roulland, Petra H.M. Peeters, Pagona Lagiou, María José Sánchez, Federico Canzian, Rosario Tumino, José Ramón Quirós, Philippe Solal-Celigny, H. Bas Bueno-de-Mesquita, Anja Olsen, Joyce Carlson, Bertrand Nadel, Elio Riboli, Paolo Vineis, Dimitrios Trichopoulos, Salvatore Panico, Signe Borgquist, Kay-Tee Khaw, Timothy J. Key, Roel Vermeulen, Carlos A. Gonzales, Ester Morgado, Françoise Clavel-Chapelon, Domenico Palli, Ruth C. Travis, Carmen Navarro, Pietro Ferrari, Philippe Colombat, Alexandra Nieters, Eiliv Lund, Rudolf Kaaks, Nicholas J. Wareham, Beatrice Melin, Carlotta Sacerdote, Heiner Boeing, Gilles Salles, Valeria Pala, Miren Dorronsoro, Göran Hallmans, Rachel S. Kelly |
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| Přispěvatelé: | Roulland, S, Kelly, R, Morgado, E, Sungalee, S, Solal Celigny, P, Colombat, P, Jouve, N, Palli, D, Pala, V, Tumino, R, Panico, Salvatore, Sacerdote, C, Quir?s, Jr, Gonz?les, Ca, S?nchez, Mj, Dorronsoro, M, Navarro, C, Barricarte, A, Tj?nneland, A, Olsen, A, Overvad, K, Canzian, F, Kaaks, R, Boeing, H, Drogan, D, Nieters, A, Clavel Chapelon, F, Trichopoulou, A, Trichopoulos, D, Lagiou, P, Bueno de Mesquita, Hb, Peeters, Ph, Vermeulen, R, Hallmans, G, Melin, B, Borgquist, S, Carlson, J, Lund, E, Weiderpass, E, Khaw, Kt, Wareham, N, Key, Tj, Travis, Rc, Ferrari, P, Romieu, I, Riboli, E, Salles, G, Vineis, P, Nadel, B., LS IRAS EEPI GRA (Gezh.risico-analyse) |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Lymphoma Follicular lymphoma Translocation Polymerase Chain Reaction Chromosomes Translocation Genetic Cohort Studies Genetic Internal medicine Biomarkers Tumor Prevalence Humans Medicine Lymphoma Follicular Aged Chromosomes Human Pair 14 Molecular Epidemiology Tumor Pair 18 business.industry Pair 14 Follicular Case-control study Odds ratio Middle Aged medicine.disease European Prospective Investigation into Cancer and Nutrition Europe International (English) Case-Control Studies Cohort Immunology Biomarker (medicine) Female Chromosomes Human Pair 18 business Biomarkers Human Cohort study |
| Zdroj: | Roulland, S, Kelly, R S, Morgado, E, Sungalee, S, Solal-Celigny, P, Colombat, P, Jouve, N, Palli, D, Pala, V, Tumino, R, Panico, S, Sacerdote, C, Quirós, J R, Gonzáles, C A, Sánchez, M-J, Dorronsoro, M, Navarro, C, Barricarte, A, Tjønneland, A, Olsen, A, Overvad, K, Canzian, F, Kaaks, R, Boeing, H, Drogan, D, Nieters, A, Clavel-Chapelon, F, Trichopoulou, A, Trichopoulos, D, Lagiou, P, Bueno-de-Mesquita, H B, Peeters, P H M, Vermeulen, R, Hallmans, G, Melin, B, Borgquist, S, Carlson, J, Lund, E, Weiderpass, E, Khaw, K-T, Wareham, N, Key, T J, Travis, R C, Ferrari, P, Romieu, I, Riboli, E, Salles, G, Vineis, P & Nadel, B 2014, ' t(14;18) Translocation : A Predictive Blood Biomarker for Follicular Lymphoma ', Journal of Clinical Oncology, vol. 32, no. 13, pp. 1347-55 . https://doi.org/10.1200/JCO.2013.52.8190 Journal of Clinical Oncology, 32(13), 1347. American Society of Clinical Oncology |
| ISSN: | 1527-7755 0732-183X |
| Popis: | Purpose The (14;18) translocation constitutes both a genetic hallmark and critical early event in the natural history of follicular lymphoma (FL). However, t(14;18) is also detectable in the blood of otherwise healthy persons, and its relationship with progression to disease remains unclear. Here we sought to determine whether t(14;18)-positive cells in healthy individuals represent tumor precursors and whether their detection could be used as an early predictor for FL. Participants and Methods Among 520,000 healthy participants enrolled onto the EPIC (European Prospective Investigation Into Cancer and Nutrition) cohort, we identified 100 who developed FL 2 to 161 months after enrollment. Prediagnostic blood from these and 218 controls were screened for t(14;18) using sensitive polymerase chain reaction–based assays. Results were subsequently validated in an independent cohort (65 case participants; 128 controls). Clonal relationships between t(14;18) cells and FL were also assessed by molecular backtracking of paired prediagnostic blood and tumor samples. Results Clonal analysis of t(14;18) junctions in paired prediagnostic blood versus tumor samples demonstrated that progression to FL occurred from t(14;18)-positive committed precursors. Furthermore, healthy participants at enrollment who developed FL up to 15 years later showed a markedly higher t(14;18) prevalence and frequency than controls (P < .001). Altogether, we estimated a 23-fold higher risk of subsequent FL in blood samples associated with a frequency > 10−4 (odds ratio, 23.17; 95% CI, 9.98 to 67.31; P < .001). Remarkably, risk estimates remained high and significant up to 15 years before diagnosis. Conclusion High t(14;18) frequency in blood from healthy individuals defines the first predictive biomarker for FL, effective years before diagnosis. |
| Databáze: | OpenAIRE |
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