Contribution of genetic variant identified in HHEX gene in the overweight Saudi patients confirmed with type 2 diabetes mellitus
| Autor: | Mohammed Alfaifi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Oncology
medicine.medical_specialty endocrine system diseases Overweight and obesity QH301-705.5 Hematopoietically expressed homeobox Population T2DM HHEX Polymorphism (computer science) Internal medicine Genotype Medicine Biology (General) education Allele frequency Genotyping Genetic association education.field_of_study biology business.industry Type 2 Diabetes Mellitus nutritional and metabolic diseases Rs7932837 biology.gene General Agricultural and Biological Sciences business |
| Zdroj: | Saudi Journal of Biological Sciences, Vol 29, Iss 2, Pp 804-808 (2022) |
| Popis: | Background: The rs7932837 polymorphism in the Hematopoietically expressed homeobox (HHEX) gene was discovered through genome-wide association studies and is a promising candidate for type 2 diabetes mellitus (T2DM), which is one of the risk factors for obesity and other complications. T2DM has been identified as a heterogeneous and multifactorial disease characterized by insulin resistance and secretion. Aim: The aim of this study was to investigate the rs7932837 polymorphism in the HHEX gene in overweight patients diagnosed with T2DM in the Saudi Population. Methods: In this case-control study, one hundred T2DM cases and 100 controls were selected based on inclusion and exclusion criteria. Genotyping was performed with polymerase chair reaction-restriction fragment length polymorphism analysis and statistical analysis was performed between T2DM cases and controls for clinical characteristics, genotype and allele frequencies and multiple logistic regression analysis. Results: In this study, T2DM cases were compared with healthy control subjects. Clinical characteristic analysis revealed the statistical analysis between age, weight, BMI, FBG, HDL-c, TC, TG and family history (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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