Chromatin fiber allostery and the epigenetic code

Autor: Annick Lesne, Nicolas Foray, Jean-Marc Victor, Thierry Forné, Guy Cathala, Hua Wong
Přispěvatelé: Administateur, HAL Sorbonne Université, Blanc 2013 - ANalyse de la DYnamique des chromosomes associée à la transcription - - ANDY2013 - ANR-13-BSV5-0010 - Blanc 2013 - VALID, Institut de Génétique Moléculaire de Montpellier (IGMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique de la Matière Condensée (LPTMC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), GDR 3536, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), Institut national de la santé et de la recherche médicale . Grant number: PC201104 MICROMEGASFrench Institut National du Cancer. Grant number: INCa-5960, ANR-13-BSV5-0010,ANDY,ANalyse de la DYnamique des chromosomes associée à la transcription(2013), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), E02, Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Institut Pasteur [Paris], Institut de Génétique Moléculaire de Montpellier ( IGMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Théorique de la Matière Condensée ( LPTMC ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherche en Cancérologie de Lyon ( CRCL ), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), ANR-13-BSV5-0010,ANDY,ANalyse de la DYnamique des chromosomes associée à la transcription ( 2013 )
Rok vydání: 2015
Předmět:
Models
Molecular
Transcription
Genetic
Epigenetic code
[PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]
Computational biology
Chromatin remodeling
Epigenesis
Genetic
Histones
03 medical and health sciences
Mice
0302 clinical medicine
Allosteric Regulation
[ PHYS.PHYS.PHYS-BIO-PH ] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]
Insulin-Like Growth Factor II
Histone code
Animals
General Materials Science
Epigenetics
030304 developmental biology
Chromatin Fiber
0303 health sciences
biology
[PHYS.PHYS.PHYS-BIO-PH] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]
Chemistry
Acetylation
DNA
DNA Methylation
Condensed Matter Physics
Linker DNA
Molecular biology
Chromatin
Histone
Allosteric enzyme
biology.protein
Nucleic Acid Conformation
030217 neurology & neurosurgery
Zdroj: Journal of Physics: Condensed Matter
Journal of Physics: Condensed Matter, 2015, 27 (6), pp.064114. ⟨10.1088/0953-8984/27/6/064114⟩
Journal of Physics: Condensed Matter, IOP Publishing, 2015, 27 (6), pp.064114. ⟨10.1088/0953-8984/27/6/064114⟩
Journal of Physics: Condensed Matter, IOP Publishing, 2015, 27 (6), pp.064114. 〈10.1088/0953-8984/27/6/064114〉
ISSN: 1361-648X
0953-8984
DOI: 10.1088/0953-8984/27/6/064114⟩
Popis: International audience; The notion of allostery introduced for proteins about fifty years ago has been extended since then to DNA allostery, where a locally triggered DNA structural transition remotely controls other DNA-binding events. We further extend this notion and propose that chromatin fiber allosteric transitions, induced by histone-tail covalent modifications, may play a key role in transcriptional regulation. We present an integrated scenario articulating allosteric mechanisms at different scales: allosteric transitions of the condensed chromatin fiber induced by histone-tail acetylation modify the mechanical constraints experienced by the embedded DNA, thus possibly controlling DNA-binding of allosteric transcription factors or further allosteric mechanisms at the linker DNA level. At a higher scale, different epigenetic constraints delineate different statistically dominant subsets of accessible chromatin fiber conformations, which each favors the assembly of dedicated regulatory complexes, as detailed on the emblematic example of the mouse Igf2-H19 gene locus and its parental imprinting. This physical view offers a mechanistic and spatially structured explanation of the observed correlation between transcriptional activity and histone modifications. The evolutionary origin of allosteric control supports to speak of an 'epigenetic code', by which events involved in transcriptional regulation are encoded in histone modifications in a context-dependent way.
Databáze: OpenAIRE
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