Anti-Tumor Activity, In Vitro and In Vivo, of Some Triphenylphosphinegold(I) Thionucleobases
| Autor: | Edward R. T. Tiekink, Silvina Rainone, Lorraine K. Webster, Ernst Horn |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pharmacology
Antitumor activity Cisplatin endocrine system diseases business.industry Toxicology medicine.disease Bioinformatics In vitro Inorganic Chemistry Text mining In vivo Cell culture Ovarian carcinoma Drug Discovery medicine Cancer research Plasmacytoma business Research Article medicine.drug |
| Zdroj: | Metal-Based Drugs |
| ISSN: | 0793-0291 |
| Popis: | The [Ph3PAu(6-MP)] complex, where 6-MPH is 6-mercaptopurine, is active against the cisplatinresistant cell line, mouse leukaemia L1210/DDP, as is the precursor compound [Ph3PAuCl], suggesting that the thiolate is not critical for activity. Against the human cell lines, FaDu (squamous cell carcinoma) and SKOV-3 (ovarian carcinoma), both [Ph3PAu(6-MP)] and [Ph3PAu(6-TG)], where 6-TGH is 6-thioguanine, were active. [Ph3PAu(6-MP)] was active against a murine PC6 plasmacytoma, but not as active as cisplatin. |
| Databáze: | OpenAIRE |
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