HIV clinical stages and lower extremity arterial disease among HIV infected outpatients in Burundi
| Autor: | Pierre-Marie Preux, Théodore Niyongabo, Philippe Lacroix, Victor Aboyans, Ileana Desormais, Deo Harimenshi |
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| Přispěvatelé: | Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Service de cardiologie [CHU Limoges], Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Arterial disease Burundi Science Population Human immunodeficiency virus (HIV) HIV Infections 030204 cardiovascular system & hematology medicine.disease_cause Severity of Illness Index Article 03 medical and health sciences 0302 clinical medicine Hiv infected Internal medicine Outpatients medicine Prevalence Humans Mass Screening Ankle Brachial Index 030212 general & internal medicine education education.field_of_study Multidisciplinary business.industry Central africa Mean age Middle Aged Atherosclerosis 3. Good health Chronic disease Cardiovascular diseases Cross-Sectional Studies Lower Extremity Hypertension Infectious diseases Medicine Female [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Stage iv business |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) Scientific Reports Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.8296. ⟨10.1038/s41598-021-87862-z⟩ |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-87862-z⟩ |
| Popis: | Chronic disease of people living with human immunodeficiency virus (HIV) infection are now approaching those of the general population. Previous, in vitro studies shown that HIV causes arterial injuries resulting in inflammation and atherosclerosis but direct relationship between HIV infection clinical stages and lower extremity arterial disease (LEAD) remain controversial. No study assessed, with an accurate method, both the prevalence of LEAD and the influence of HIV severity on LEAD in HIV outpatients in Central Africa. A cross-sectional study was conducted among 300 HIV-infected outpatients, aged ≥ 40 years in Bujumbura, Burundi. All patients underwent ankle-brachial index (ABI) measurement and LEAD was diagnosed by ABI ≤ 0.9. The prevalence of LEAD was 17.3% (CI 95% 13.2–22.1). The mean age was 49.6 ± 7.1 years. On multivariable analysis, factors associated with LEAD were hypertension (OR = 2.42; 95% CI 1.10–5.80), and stage IV HIV clinical infection (OR = 4.92, 95% CI 1.19–20.36). This is the first study performed on a large HIV population in Central Africa, reporting high LEAD prevalence. It underlines the influence of HIV infection on peripheral atherosclerosis at latest clinical stages and the need for LEAD screening in HIV-infected patients. |
| Databáze: | OpenAIRE |
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