Natural history of cartilage damage and osteoarthritis progression on magnetic resonance imaging in a population-based cohort with knee pain
| Autor: | Eric C. Sayre, Jolanda Cibere, Jacek A. Kopec, Ali Guermazi, Anona Thorne, Joel Singer, John M. Esdaile, S. Nicolaou, Hubert Wong |
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| Rok vydání: | 2011 |
| Předmět: |
Cartilage
Articular Male medicine.medical_specialty Knee Joint Population Biomedical Engineering Osteoarthritis Cohort Studies Rheumatology Internal medicine medicine Humans Orthopedics and Sports Medicine education Aged education.field_of_study Progression medicine.diagnostic_test business.industry Cartilage Early disease Hazard ratio Cohort Magnetic resonance imaging Middle Aged Osteoarthritis Knee medicine.disease Magnetic Resonance Imaging Surgery Radiography medicine.anatomical_structure Knee pain Disease Progression Female Knee osteoarthritis medicine.symptom business MRI Cohort study |
| Zdroj: | Osteoarthritis and Cartilage. 19:683-688 |
| ISSN: | 1063-4584 |
| Popis: | Summary Objectives To determine the natural history of cartilage damage and of osteoarthritis (OA) progression using magnetic resonance imaging (MRI); to evaluate whether OA progression varies by stage of disease. Methods A population-based cohort with knee pain was assessed clinically, with X-ray (Kellgren–Lawrence [KL] grading) and MRI. Cartilage was graded 0–3 on six joint surfaces. Frequency of cartilage damage change was determined for each joint site. Progression of OA was defined as a worsening of MRI cartilage damage by ≥1 grade in at least two joint sites or ≥2 grades in at least one joint site. The association of KL grade with OA progression was evaluated using parametric lifetime regression analysis. Results 163 subjects were assessed at baseline and follow-up (mean 3.2 years). KL grade ≥2 was present in 39.4% at baseline. An increase in cartilage damage by ≥1 grade was seen in 8.0–14.1% of subjects at different joint sites. OA progression on MRI was present in 15.5%. Baseline KL grade was a significant predictor of OA progression with hazard ratio (HR) of 6.5 (95% confidence interval [CI] 1.4–30.7), 6.1 (95% CI 1.3–28.9), and 9.2 (95% CI 1.9–44.9) for KL grades 1, 2 and ≥3, respectively. Conclusion A low OA progression rate was seen over 3 years in this population-based symptomatic cohort. Radiographic severity, including KL grade 1, was a significant predictor of OA progression. Future interventions aimed at reducing progression will need to target not only radiographic OA, but also those with early abnormalities suggestive of pre-radiographic OA. |
| Databáze: | OpenAIRE |
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