The Antinociceptive Effect of (-)-Linalool in Models of Chronic Inflammatory and Neuropathic Hypersensitivity in Mice
| Autor: | Maria Fernanda de Paula Werner, Gina M. Story, Patricia Aparecida Batista, Leonel Burgos, Erica Carvalho Oliveira, Patrícia Pereira, Lucimar Filot da Silva Brum, Adair R.S. Santos |
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| Rok vydání: | 2010 |
| Předmět: |
Acyclic Monoterpenes
medicine.medical_treatment Freund's Adjuvant Inflammation Pharmacology Mice chemistry.chemical_compound Adjuvants Immunologic Linalool medicine Animals Hyperesthesia business.industry Disease Models Animal Anesthesiology and Pain Medicine Nociception Biting Neurology chemistry Hyperalgesia Anesthesia Chronic Disease Neuropathic pain Monoterpenes Neuralgia Female Neurology (clinical) Sciatic nerve Inflammation Mediators Sciatic Neuropathy medicine.symptom Ligation business Adjuvant |
| Zdroj: | The Journal of Pain. 11:1222-1229 |
| ISSN: | 1526-5900 |
| Popis: | We used multiple pain models to investigate the effects of (-)-linalool, a monoterpene alcohol present in the essential oil of plants, on chronic inflammatory and neuropathic hypersensitivity in adult Swiss mice. Inflammatory or neuropathic hypersensitivity was induced by intraplantar (i.pl.) injection of complete Freund's adjuvant (CFA) or partial sciatic nerve ligation (PSNL), respectively. Twenty-four hours after CFA injection, we used Von Frey filaments and acetone-evoked cooling to evaluate tactile and thermal hypersensitivity, respectively. A single i.p. injection of (-)-linalool (50 or 200 mg/kg) administered 30 minutes before testing reduced CFA-induced mechanical hypersensitivity. Similarly, (-)-linalool reduced acetone-evoked hypersensitivity up to 4 hours after treatment. Compared with vehicle, (-)-linalool produced a marked reduction in CFA-induced paw edema. (-)-Linalool also reduced mechanical hypersensitivity induced by PSNL 7 days after injury. Multiple (-)-linalool treatments given chronically (twice a day for 10 days; 50 mg/kg, i.p.) significantly reduced mechanical hypersensitivity induced by CFA and PSNL. This multidose strategy did not cause tolerance. We also reasoned that (-)-linalool might reduce nociceptive behavior in response to direct administration of inflammatory mediators. Therefore, we injected the cytokines IL-1β (.1 pg/site) and TNF-α (1 pg/site) intrathecally. (-)-Linalool inhibited the biting response induced by IL-1β and TNF-α. Perspective The article adds information about antinociceptive properties of (-)-linalool in chronic inflammatory and neuropathic hypersensitivity. It also indicates that (-)-linalool might be potentially interesting in the development of new clinically relevant drugs for the management of persistent pain. |
| Databáze: | OpenAIRE |
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