Preparation and enhanced mechanical properties of hybrid hydrogels comprising ultralong hydroxyapatite nanowires and sodium alginate
| Autor: | Ying-Jie Zhu, Yong-Gang Zhang, Tuan-Wei Sun, Feng Chen, Ying-Ying Jiang, Yue-Qin Shen, Heng Li |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Biocompatibility Alginates Nanowire Nanoparticle macromolecular substances 02 engineering and technology 010402 general chemistry complex mixtures 01 natural sciences Biomaterials Colloid and Surface Chemistry Glucuronic Acid Ultimate tensile strength Nanocomposite Nanowires Hexuronic Acids technology industry and agriculture Hydrogels 021001 nanoscience & nanotechnology 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Durapatite Compressive strength Chemical engineering Self-healing hydrogels 0210 nano-technology Drug carrier |
| Zdroj: | Journal of Colloid and Interface Science. 497:266-275 |
| ISSN: | 0021-9797 |
| DOI: | 10.1016/j.jcis.2017.03.032 |
| Popis: | Hydrogels with 3-dimentional cross-linked structures are widely used in various biomedical fields such as bone repair scaffolds, drug carriers and biosensors. However, the applications of hydrogels are usually restricted because of their poor mechanical properties. Currently, nanocomposites, double network systems, hydrophobic association, macromolecules, and nanoparticles are commonly adopted as cross-linking agents to enhance mechanical properties of hydrogels. In this work, ultralong hydroxyapatite nanowires (HANWs) with lengths of several hundred microns are prepared and used to enhance the mechanical properties of sodium alginate (SA)-based hydrogels. Using divalent calcium ions as the cross-linking agent, the hybrid HANWs/SA hydrogels containing various percentages of HANWs are obtained. The as-prepared HANWs/SA hybrid hydrogels have a porous structure with pore sizes ranging from about 200 to 500μm. The mechanical properties of SA hydrogels can be significantly improved by incorporating HANWs. The maximum compressive modulus (E50%) and tensile Young's modulus of the hybrid hydrogel (HANWs/SA=2:1) are as high as 0.123MPa and 0.994MPa, which are about 162% and 614% those of the pure SA hydrogel, respectively. Due to the enhanced mechanical properties and high biocompatibility, the as-prepared HANWs/SA hybrid hydrogels have promising applications in various biomedical fields such as bone defect repair. |
| Databáze: | OpenAIRE |
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