Chloroquine-containing compounds: a patent review (2010 – 2014)
| Autor: | Nicholas M. Njuguna, Paul M. Njaria, Kelly Chibale, John Okombo |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
hydroxychloroquine
Plasmodium falciparum malaria repurposing Review chloroquine derivatives Pharmacology Patents as Topic Aminoquinoline Antimalarials Chloroquine Drug Discovery medicine cancer Animals Humans Repurposing Biological evaluation repositioning antimalarial biology business.industry Drug Repositioning Stereoisomerism aminoquinoline General Medicine biology.organism_classification medicine.disease patent Drug Design business Malaria medicine.drug |
| Zdroj: | Expert Opinion on Therapeutic Patents |
| ISSN: | 1744-7674 1354-3776 |
| Popis: | Introduction: Chloroquine (CQ) has been well known for its antimalarial effects since World War II. However, it is gradually being phased out from clinical use against malaria due to emergence of CQ-resistant Plasmodium falciparum strains. Besides low cost and tolerability, ongoing research has revealed interesting biochemical properties of CQ that have inspired its repurposing/repositioning in the management of various infectious/noninfectious diseases. Consequently, several novel compounds and compositions based on its scaffold have been studied and patented. Areas covered: In this review, patents describing CQ and its derivatives/compositions over the last 5 years are analyzed. The review highlights the rationale, chemical structures, biological evaluation and potential therapeutic application of CQ, its derivatives and compositions. Expert opinion: Repurposing efforts have dominantly focused on racemic CQ with no studies exploring the effect of the (R) and (S) enantiomers, which might potentially have additional benefits in other diseases. Additionally, evaluating other similarly acting antimalarials in clinical use and structural analogs could help maximize the intrinsic value of the 4-aminoquinolines. With regard to cancer therapy, successful repurposing of CQ-containing compounds will require linking the mode of action of these antimalarials with the signaling pathways that drive cancer cell proliferation to facilitate the development of a 4-amino-7-chloroquinoline that can be used as a synergistic partner in anticancer combination chemotherapy. |
| Databáze: | OpenAIRE |
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