Allogeneic haematopoietic stem cell transplantation in patients with human immunodeficiency virus: the experiences of more than 25 years
| Autor: | G. Hütter, J. A. Zaia |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
business.industry
Genetic enhancement Immunology Hematopoietic Stem Cell Transplantation Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Peripheral blood Transplantation Haematopoiesis surgical procedures operative medicine.anatomical_structure Hematologic Neoplasms medicine Humans Immunology and Allergy In patient Bone marrow Stem cell business Review Articles |
| Zdroj: | Clinical and Experimental Immunology. 163:284-295 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/j.1365-2249.2010.04312.x |
| Popis: | Summary For treatment of several malignancies, transplantation of allogeneic haematopoietic stem cells (HSCT) derived from bone marrow or peripheral blood has been used as a therapeutic procedure for decades. In the past, HSCT has been suggested as a treatment option for infection with the human immunodeficiency virus type 1 (HIV-1), but these attempts were mostly unsuccessful. Today, after the introduction of an active anti-retroviral therapy, the lifetime expectancy of HIV-infected patients has improved substantially, but nevertheless the incidence rate of malignancies in these patients has increased considerably. Therefore, it can be assumed that there will be a rising necessity for HIV-1-infected patients with malignancies for allogeneic HSCT. At the same time, there is increasing interest in treatment methods which might target the HIV-1 reservoir more effectively, and the question has been raised as to whether allogeneic HSCT could be linked to such strategies. In this paper the data of more than 25 years experience with allogeneic HSCT in patients with HIV-1 are reviewed and analysed. |
| Databáze: | OpenAIRE |
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