Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019
| Autor: | Marie-Louise von Linstow, Didi Bang, Nikolai Kirkby, Alex C. Y. Nielsen, Anja Poulsen, Thilde Nordmann Winther, Anna Korsgaard Eltvedt, Allan Bybeck Nielsen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Epidemiology Denmark Health Personnel education Antibodies Viral Measles Rubella Antibodies Serology Seroepidemiologic Studies Virology Humans Medicine Seroprevalence Child Mumps seroprevalence healthcare workers business.industry Research Diphtheria Vaccination Public Health Environmental and Occupational Health Outbreak medicine.disease immunity vaccine-preventable diseases Female Vaccine-preventable diseases business Measles-Mumps-Rubella Vaccine |
| Zdroj: | Eurosurveillance |
| ISSN: | 1560-7917 |
| DOI: | 10.2807/1560-7917.es.2021.26.17.2001167 |
| Popis: | Background Healthcare workers (HCW) have been identified as index cases in disease outbreaks of vaccine-preventable diseases (VPD) in hospitals. Aim We investigated whether Danish paediatric HCW were protected against selected serious VPD. Methods We included 90% of staff members from two paediatric departments. All 555 HCW (496 women) supplied a blood sample for serology and filled in a questionnaire. Antibodies were measured with enzyme immunoassay against measles, mumps, rubella (MMR), varicella zoster, pertussis toxin and diphtheria toxin. Results Protective levels of IgG were found for measles (90.3%), mumps (86.5%), rubella (92.3%), varicella (98.6%) and diphtheria (80.5%). We found seropositivity for all three MMR components in 421 (75.9%) HCW, lowest in those younger than 36 years (63.3%). Only 28 (5%) HCW had measurable IgG to pertussis. HCW with self-reported immunity defined as previous infection or vaccination, had protective levels of IgG against measles, mumps, rubella and varicella in 87.4–98.8% of cases, not significantly higher than in those not reporting immunity. Previous history of disease had a high positive predictive value (PPV) of 96.8–98.8%. The PPV for previous vaccination ranged from 82.5% to 90.3%. In contrast, negative predictive values of self-reported history of disease and vaccination were remarkably low for all diseases. Conclusion The immunity gaps found primarily in young HCW indicate a need for a screening and vaccination strategy for this group. Considering the poor correlation between self-reported immunity and seropositivity, efforts should be made to check HCW’s immune status in order to identify those who would benefit from vaccination. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|