Comparative Performance of Linear Multielectrode Probes and Single-Tip Electrodes for Intracortical Microstimulation and Single-Neuron Recording in Macaque Monkey
| Autor: | Marco Lanzilotto, Monica Maranesi, Carolina Giulia Ferroni, Luca Bonini, Alessandro Livi |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Hand region Materials science Cognitive Neuroscience Neuroscience (miscellaneous) Acute recording Chronic recording Electrical stimulation Macaque monkey Silicon probes Developmental Neuroscience Cellular and Molecular Neuroscience Macaque chronic recording 03 medical and health sciences 0302 clinical medicine biology.animal medicine Premovement neuronal activity silicon probes electrical stimulation Original Research biology technology industry and agriculture equipment and supplies macaque monkey Microelectrode 030104 developmental biology Intracortical microstimulation medicine.anatomical_structure Electrode acute recording Neuron 030217 neurology & neurosurgery Biomedical engineering Motor cortex Neuroscience |
| Zdroj: | Frontiers in Systems Neuroscience |
| ISSN: | 1662-5137 |
| Popis: | Intracortical microstimulation (ICMS) is one of the most widely employed techniques for providing causal evidence of the relationship between neuronal activity and specific motor, perceptual, or even cognitive functions. In recent years, several new types of linear multielectrode silicon probes have been developed, allowing researchers to sample neuronal activity at different depths along the same cortical site simultaneously and with high spatial precision. Nevertheless, silicon multielectrode probes have been rarely employed for ICMS studies and, more importantly, it is unknown whether and to what extent they can be used for combined recording and stimulation experiments. Here, we addressed these issues during both acute and chronic conditions. First, we compared the behavioral outcomes of ICMS delivered to the hand region of a monkey’s motor cortex with multielectrode silicon probes, commercially available multisite stainless-steel probes and single-tip glass-coated tungsten microelectrodes. The results for all three of the probes were reliable and similar. Furthermore, we tested the impact of long-train ICMS delivered through chronically implanted silicon probes at different time intervals, from 1 to 198 days after ICMS sessions, showing that although the number of recorded neurons decreased over time, in line with previous studies, ICMS did not alter silicon probes’ recording capabilities. These findings indicate that in ICMS experiments, the performance of linear multielectrode silicon probes is comparable to that of both single-tip and multielectrode stainless-steel probes, suggesting that the silicon probes can be successfully used for combined recording and stimulation studies in chronic conditions. |
| Databáze: | OpenAIRE |
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