Longitudinal changes in body composition are associated with all-cause mortality in patients on peritoneal dialysis

Autor: Young Rim Song, Sung Gyun Kim, Cheolsu Kim, Hyung Seok Lee, Jwa-Kyung Kim
Rok vydání: 2021
Předmět:
Adult
Male
0301 basic medicine
Sarcopenia
medicine.medical_specialty
medicine.medical_treatment
Nutritional Status
Adipose tissue
030209 endocrinology & metabolism
Negative association
Critical Care and Intensive Care Medicine
Gastroenterology
Body Mass Index
Peritoneal dialysis
03 medical and health sciences
0302 clinical medicine
Bioimpedance spectroscopy
Risk Factors
Cause of Death
Internal medicine
Electric Impedance
Prevalence
medicine
Humans
In patient
Longitudinal Studies
Wasting
Aged
Retrospective Studies
030109 nutrition & dietetics
Nutrition and Dietetics
Hand Strength
business.industry
Middle Aged
medicine.disease
Adipose Tissue
Dielectric Spectroscopy
Body Composition
Kidney Failure
Chronic
Body-Weight Trajectory
Female
sense organs
medicine.symptom
business
Peritoneal Dialysis
All cause mortality
Zdroj: Clinical Nutrition. 40:120-126
ISSN: 0261-5614
DOI: 10.1016/j.clnu.2020.04.034
Popis: Peritoneal dialysis (PD) is associated with a number of adverse body compositional changes, including fat gain and muscle wasting. Whether body compositional changes are associated with the long-term prognosis is uncertain. The purpose of this study was to analyze the effects of longitudinal changes in body composition on all-cause mortality in PD patients.PD patients were subjected to bioimpedance spectroscopy (BIS) and handgrip strength (HGS) at baseline and after 2 years. Among 160 patients, 131 patients were tested with a repeat BIS and HGS. Lean tissue index (LTI) loss and fat tissue index (FTI) gain were defined as a 10% decline in LTI and a 10% gain in FTI, respectively after 2 years.The prevalence of sarcopenia at baseline was 13.8%. After 2 years, LTI loss and FTI gain were observed in 40 (30.5%) and 58 (44.3%) patients, respectively. Baseline clinical factors did not predict longitudinal body compositional changes, and there was a negative association between changes in the LTI and FTI (r = -0.574, p 0.001). Low LTI and low HGS at baseline were significant predictors of all-cause mortality after adjusting for demographic and biochemical parameters, but not when cardiovascular factors were included in the multivariate analysis. However, LTI loss and FTI gain were independent risk factors for all-cause mortality after adjusting for demographic, biochemical, and cardiovascular parameters.In PD patients, longitudinal changes in LTI and FTI were more strongly associated with all-cause mortality than single values in LTI and FTI.
Databáze: OpenAIRE
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