DEVELOPMENT AND VALIDATION OF THE REAL-WORLD PROGRESSION IN DIABETES (RAPIDS) MODEL
| Autor: | Brian Bartle, Jennifer M. Cooper, Kwun Chuen Gary Chan, Anirban Basu, Min-Woong Sohn, Elbert S. Huang |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male Comparative Effectiveness Research Databases Factual Computer science Comparative effectiveness research Blood Pressure Type 2 diabetes Models Biological Article Medication Adherence 03 medical and health sciences 0302 clinical medicine Diabetes mellitus medicine Humans Hypoglycemic Agents 030212 general & internal medicine Aged Glucose lowering Actuarial science 030503 health policy & services Health Policy Reproducibility of Results Middle Aged medicine.disease Hypoglycemia United States United States Department of Veterans Affairs Cholesterol Treatment Outcome Diabetes Mellitus Type 2 Female 0305 other medical science Real world data Biomarkers Follow-Up Studies |
| Popis: | To develop and validate the first real-world data-based type 2 diabetes progression model (RAPIDS) employing econometric techniques that can study the comparative effects of complex dynamic patterns of glucose-lowering drug use.The US Department of Veterans Affairs (VA) electronic medical record and claims databases were used to identify over 500,000 diabetes patients in 2003 with up to 9-year follow-up. The RAPIDS model contains interdependent first-order Markov processes over quarters for each of the micro- and macrovascular events, hypoglycemia, and death, as well as predictive models for 8 biomarker levels. Model parameters varied by static demographic factors and dynamic factors, such as age, duration of diabetes, 13 possible glucose-lowering treatment combinations, any blood pressure and any cholesterol-lowering medications, and cardiovascular history. To illustrate model capabilities, a simple comparative study was set up to compare observed treatment use patterns to alternate patterns if perfect adherence is assumed following initiating the use of any of these medications.Data were randomly split into 307,288, 105,195, and 105,081 patients to perform estimation, out-of-sample calibration, and validation, respectively. Model predictions in the validation sample closely aligned with the observed longitudinal trajectory of biomarkers and outcomes. Perfect adherence among initiators increased proportion of days covered by only 6 months. Most of this increase came from increased adherence to monotherapies and did not lead to meaningful changes in any of the outcomes over the 9-year period.Future value of increasing medication adherence among VA patients with diabetes may lie among those who never initiate treatment or are late in initiating treatment. The first-of-its-kind real-world data-based model has the potential to carry out many complex comparative-effectiveness research (CER) studies of dynamic glucose-lowering drug regimens. |
| Databáze: | OpenAIRE |
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