Antibiotic therapy for enterobacter meningitis: a retrospective review of 13 episodes and review of the literature
| Autor: | Marcos A. Wolff, Reuben Ramphal, Clarence L. Young |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty medicine.drug_class Antibiotics Enterobacter Drug resistance Meningitis Bacterial Anti-Infective Agents Internal medicine Trimethoprim Sulfamethoxazole Drug Combination medicine Humans Intensive care medicine Child Antibacterial agent Aged Retrospective Studies 4-Quinolones biology business.industry Sulfamethoxazole Enterobacteriaceae Infections Drug Resistance Microbial Middle Aged bacterial infections and mycoses medicine.disease biology.organism_classification Trimethoprim Anti-Bacterial Agents Cephalosporins Infectious Diseases Aminoglycosides Treatment Outcome Bacteremia Female business Meningitis medicine.drug Follow-Up Studies |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 16(6) |
| ISSN: | 1058-4838 |
| Popis: | Enterobacter meningitis is an uncommon form of meningitis whose treatment poses a therapeutic dilemma because of the development of resistance to the third-generation cephalosporins while the patient receives therapy. In recent years, we have been using trimethoprim-sulfamethoxazole (TMP-SMZ) as treatment for this infection. In this report, we reviewed 13 episodes of enterobacter meningitis that were treated with various antibiotic regimens and 33 episodes from the literature. We found that the development of resistance to beta-lactam agents may be much higher than that seen in bacteremias (approximately 30%), that the case-fatality rate is lower among our patients than among those described previously, and that all patients who received TMP-SMZ were cured, compared with about 70% of those receiving beta-lactam agents. TMP-SMZ appears to be an acceptable alternative to the cephalosporins for the treatment of enterobacter meningitis. |
| Databáze: | OpenAIRE |
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