Frequency of rare, serious donor reactions
| Autor: | Whitney R. Steele, Nancy L Van Buren, Joanne Pink, Biomedical Excellence for Safer Transfusion (Best) Collaborative, Nicholas William O'Sullivan, Katja van den Hurk, Beth H. Shaz, Merlyn H. Sayers, David O. Irving, Ana Paula Hitomi Yokoyama, Ramir Alcantara, Pampee P. Young, Jose Mauro Kutner, Lauren A. Crowder, Johanna C. Wiersum-Osselton |
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| Přispěvatelé: | Public and occupational health |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Immunology Population Blood Donors 030204 cardiovascular system & hematology Vasovagal Reaction Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Syncope Vasovagal medicine Humans Immunology and Allergy education Adverse effect Aged Venous Thrombosis education.field_of_study business.industry Incidence Cellulitis Hematology Middle Aged medicine.disease Venous thrombosis Systemic reaction Blood donor Donation Blood Component Removal Female business 030215 immunology |
| Zdroj: | The Biomedical Excellence for Safer Transfusion (BEST) Collaborative 2021, ' Frequency of rare, serious donor reactions : International perspective ', Transfusion, vol. 61, no. 6, pp. 1780-1788 . https://doi.org/10.1111/trf.16333 Transfusion, 61(6), 1780-1788. Wiley-Blackwell |
| ISSN: | 0041-1132 |
| DOI: | 10.1111/trf.16333 |
| Popis: | Background: Severe blood donor adverse events are rare, but due to their rarity studying them can be difficult. To get an accurate estimate of their frequency and rate in the donor population it may be necessary to combine donation data across countries. Study Design and Methods: International blood collection organizations (BCOs) provided data on rare/severe donor reactions as well as denominator information for their donor populations from 2015 to 2017. Donor reactions were classified using standardized definitions. Results: BCOs from six countries provided reaction data for more than 22 million donations. A total of 480 rare reactions were reported of which 76.7% were imputed as definite and 11% probable. Rates of rare reactions were higher in females and first-time donors. Systemic rare reactions were the most common reaction type, accounting for over three quarters of reactions reported. Of systemic reactions, vasovagal reactions with loss of consciousness and injury or off-site (n = 350) made up the majority and occurred 1.53 per 100,000 donations. For the 22.3% that were localized reactions, the majority of these were cellulitis (n = 71, 0.31 per 100,000 donations) followed by deep venous thrombosis (n = 21, 0.09 per 100,000 donations). Conclusion: Pulling together data from multiple BCOs across countries allows for a better understanding of rare reactions, such as vasovagal reaction with injury or cellulitis, and for generating a reliable incidence rate for air embolism or compartment syndrome. However, gaps remain due to missing elements such as unknown donor status or location of reaction. |
| Databáze: | OpenAIRE |
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