Bone marrow mastocytosis in dogs with myelosuppressive monocytic ehrlichiosis (Ehrlichia canis): a retrospective study
| Autor: | Mathios E. Mylonakis, Leonidas Leontides, Alex F. Koutinas |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Pathology medicine.medical_specialty Ehrlichia canis Bone Marrow Cells Severity of Illness Index Group A Group B Diagnosis Differential Dogs Prevalence medicine Animals Dog Diseases Retrospective Studies Doxycycline Chi-Square Distribution General Veterinary biology business.industry Ehrlichiosis Case-control study biology.organism_classification Mast cell Anti-Bacterial Agents Blood Cell Count Treatment Outcome Canis medicine.anatomical_structure Case-Control Studies Female Bone marrow business Mastocytosis medicine.drug |
| Zdroj: | Veterinary Clinical Pathology. 35:311-314 |
| ISSN: | 0275-6382 |
| DOI: | 10.1111/j.1939-165x.2006.tb00137.x |
| Popis: | Background Bone marrow mastocytosis has been reported rarely in naturally occurring canine monocytic ehrlichiosis (CME). Objectives The aims of the present study were to estimate the prevalence and magnitude of bone marrow mastocytosis in a case series of dogs with natural CME and to assess the association, if any, between mastocytosis and the clinical severity of the disease. Methods Seventy-six dogs with confirmed CME (Ehrlichia canis) were included in the study. Affected dogs were allocated into group A (n = 51) without bone marrow hypoplasia and group B (n = 25) with bone marrow hypoplasia. Twenty clinically healthy Beagles not previously exposed to E canis served as controls (group C). The main inclusion criteria for group A were documentation of normocellular to hypercellular bone marrow and complete clinical cure following a 4-week treatment with doxycycline, while those for group B were bone marrow hypoplasia and lack of response to doxycycline. Bone marrow aspirate smears from all 96 dogs were Giemsa-stained and examined for the presence of mast cells, which were calculated as a percentage of 1,000 nucleated cells (NCs). The prevalence of mastocytosis was compared among the 3 groups by the Pearson's chi-square test. Results Bone marrow mastocytosis (>0.1% of NCs) was found in 5 (20%) dogs in group B (range, 0.5-2.5% of NCs; median, 1% of NCs). One dog in each of groups A and C had 0.1% mast cells in the marrow. The prevalence of bone marrow mastocytosis in dogs in group B was significantly higher (P = .004) than in groups A and C. Conclusion Bone marrow mastocytosis can be seen in a substantial number of dogs with E canis-induced myelosuppression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text