Assisted reproductive technology outcomes in women with a chronic viral disease
| Autor: | Chloé Maignien, Pietro Santulli, Louis Marcellin, Khaled Pocate Cheriet, Odile Launay, Catherine Patrat, Emmanuel Dulioust, Charles Chapron, Mathilde Bourdon, Alicia Garnier, Philippe Sogni |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pregnancy Rate medicine.medical_treatment Birth weight media_common.quotation_subject Immunology HIV Infections Fertility Fertilization in Vitro Cohort Studies 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans Immunology and Allergy Sperm Injections Intracytoplasmic 030212 general & internal medicine Ovarian reserve media_common Assisted reproductive technology Obstetrics business.industry virus diseases Confidence interval Discontinuation 030104 developmental biology Infectious Diseases Female business Live birth Cohort study |
| Zdroj: | AIDS. 35:1073-1081 |
| ISSN: | 1473-5571 0269-9370 |
| DOI: | 10.1097/qad.0000000000002859 |
| Popis: | Objective The aim of this study was to evaluate the cumulative live birth rate in women undergoing in-vitro fertilization/intracytoplasmic-sperm-injection (IVF/ICSI) according to the type of chronic viral infection [HIV, hepatitis-B virus (HBV) and hepatitis-C virus (HCV)]. Design A cohort study. Setting A tertiary-care university hospital. Participants Women with a chronic viral illness HIV, HBV or HCV- were followed until four IVF/ICSI cycles had been completed, until delivery or until discontinuation of the treatment before the completion of four cycles. Main outcome measures The primary outcome was the cumulative live birth rate after up to four IVF/ICSI cycles. Results A total of 235 women were allocated to the HIV-infected group (n = 101), the HBV-infected group (n = 114) and the HCV-infected group (n = 20). The cumulative live birth rate after four cycles was significantly lower in the HIV-infected women than in those with HBV [39.1%, 95% confidence interval (95% CI): 17.7-60.9 versus 52.8%, 95% CI: 41.6-65.5, respectively; P = 0.004]. Regarding the obstetrical outcomes, the mean birth weight was lower in the HIV-infected women than in those with HBV or HCV. Multivariate analysis indicated that the age, the anti-Mullerian hormone and the number of cycles performed were significantly associated with the chances of a live birth. Conclusion HIV-infected women had lower cumulative live birth rate than women with chronic hepatitis, and this was due to less favourable ovarian reserve parameters. These findings underscore the need to better inform practitioners and patients regarding fertility issues and the importance of early fertility assessment. However, larger studies are necessary to gain more in-depth knowledge of the direct impact of HIV on live birth rates. |
| Databáze: | OpenAIRE |
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